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Recombinant Drosophila melanogaster Transmembrane GTPase Marf (Marf), partial

Recombinant Drosophila melanogaster Transmembrane GTPase Marf (Marf), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Marf

Purity

>85% (SDS-PAGE)

Target Names

Marf

Uniprot NO.

Q7YU24

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondrial fusion is the physical merging of mitochondria that gives rise to mitochondrial networks, and this process is counterbalanced by mitochondrial fission which fragments networks. Promotes, but is not required for park recruitment to dysfunctional mitochondria.

Gene References into Functions

Enhancing the profusion gene mitofusin/marf is beneficial in an in vivo model of TDP-43 proteinopathies, serving as a potential therapeutic target. PMID:28324764
activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria. PMID:27336715
Clu is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu-deficient flies and is destabilized upon Clu overexpression. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance. PMID:26931463
lack of ChChd3 leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki). Furthermore, loss of ChChd3 induces oxidative stress and activates the JNK pathway. In addition, depletion of other mitochondrial fusion components, Opa1 or Marf, inactivates the Hippo pathway as well. PMID:27317679
Marf is required for mitochondrial fusion and transport in long axons. PMID:25313867
Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects. PMID:24469638
Parkin deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin. PMID:24192653
mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology PMID:22957060
Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf. PMID:21475305
MARF and Opa1 control mitochondrial and cardiac function in Drosophila. PMID:21148429
The PINK1/Parkin pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies. PMID:20194754
Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line. PMID:12128227

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Subcellular Location

Mitochondrion outer membrane; Multi-pass membrane protein.

Protein Families

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, Mitofusin subfamily

Tissue Specificity

Widely expressed in embryos, accumulating in the mesoderm and endoderm during gut development. In the male germ line, it is expressed in spermatogonia, spermatocytes and early spermatids.

Database Links

UNIGENE: Dm.11038

KEGG: dme:Dmel_CG3869

STRING: 7227.FBpp0070873

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