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Recombinant Drosophila melanogaster Tachykinins (Tk)

Recombinant Drosophila melanogaster Tachykinins (Tk)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

Q9VGE8

Alternative Names

Tk; CG14734; Tachykinins; dTk) [Cleaved into: Tachykinin-related peptide 1; TK-1; dTK-1; APTSSFIGMR-amide); Tachykinin-associated peptide 1; TAP1; DEEHDTSEGNWLGSGPDPLDYADEEADSSYAEN-amide); Tachykinin-related peptide 2; TK-2; dTK-2; APLAFVGLR-amide); Tachykinin-associated peptide 2; TAP2; FIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAV-amide); Tachykinin-related peptide 3; TK-3; dTK-3; APTGFTGMR-amide); Tachykinin-associated peptide 3; TAP3; Brain peptide PALLAGDDDAEADEATELQQ); Tachykinin-related peptide 4; TK-4; dTK-4; APVNSFVGMR-amide); Tachykinin-associated peptide 4; TAP4; Brain peptide DVSHQHY); Tachykinin-associated peptide 5; TAP5; AALSDSYDLRGKQQRFADFNSKFVAVR-amide); Tachykinin-associated peptide 6; TAP6; Brain peptide SDLEGNGVGIGDDHEQALVHPWLYLWGE); Tachykinin-related peptide 5; TK-5; dTK-5; APNGFLGMR-amide)]

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

50-59

Target Protein Sequence

A PTSSFIGMR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Cytoplasmic domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions. Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which leads to courtship suppression through release of tachykinin from a cluster of 8-10 neurons in the SEZ.

Gene References into Functions

These results highlight a conserved role for Tachykinin signaling in regulating nociception. PMID:26575288
Study identified a small group of sexually dimorphic, FruM+ neurons that promote aggressiveness in Drosophila males but have no influence on male-female courtship behavior. These neurons enhance aggression, at least in part, through the release of a neuropeptide, Drosophila tachykinin. PMID:24439378
The control of DILP5 signaling in the renal tubules by Drosophila tachykinin peptide (DTK) and its receptor DTKR during desiccative, nutritional and oxidative stress, was investigated. PMID:21572965
The distribution of the Dtk transcript and peptides was analyzed by in situ hybridization and immunocytochemistry during postembryonic development of the central nervous system (CNS) of Drosophila. PMID:12898611

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Subcellular Location

Secreted.

Protein Families

Tachykinin family

Tissue Specificity

Strong expression is seen in a group of 14 cells plus one isolated cell in the midgut of stage 17 embryos. Also expressed in a pair of medially located unidentified cells, just posterior to the brain, and in two lateral groups of cells that may be associa

Database Links

UNIGENE: Dm.3420

KEGG: dme:Dmel_CG14734

STRING: 7227.FBpp0081962

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