Home
Product
Protein
Recombinant Proteins
Recombinant Drosophila melanogaster Sterile alpha and TIR motif-containing protein 1 (Ect4), partial

Recombinant Drosophila melanogaster Sterile alpha and TIR motif-containing protein 1 (Ect4), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

Ect4

Purity

>85% (SDS-PAGE)

Target Names

Ect4

Uniprot NO.

Q6IDD9

Alternative Names

Ect4; dsarm; CG43119; NAD(+) hydrolase sarm1; NADase sarm1; EC 3.2.2.6; Sterile alpha and TIR motif-containing protein 1; dSarm; Tir-1 homolog

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-1360

Target Protein Sequence

MKAAEIKRDL TNIQKSMSEI NDLAKERITG GPGSISTTSA SAITAPSTMS QTTTSRLAPK LTSAHPSIDD LRGLSRQDKI TQLQKKIRAS FENLVDHDDS NVIVTLPDDD DCPHNHFGSG LNLTHPTAAQ LSASGLSGSS KTIDTIKFQE KSMKTESKTK VVTDGFSSEQ ATSNSAEMKR LQAGDIDYQE SKGASAMRNR LEVDGVKTEE NAAVIKEALS LRTGDITQQA SNNVAASSIT VQSENFSADK KAISQSQQSQ TMTSNGIISQ EKHVSSASQA NYSMSHKGVS STGSSMITSS SQMSAMNGQM LKLADLKLDD LKSLTAGSGQ QEIEQTINKY SNMLTSIVSS LQEDERGGSA ITVHDVGGKK SQYLEKINEV IRRAWAVPTH GHELGYSLCN SLRQSGGLDL LMKNCVKPDL QFSSAQLLEQ CLTTENRKHV VDNGLDKVVN VACVCTKNSN MEHSRVGTGI LEHLFKHSEG TCSDVIRLGG LDAVLFECRT SDLETLRHCA SALANLSLYG GAENQEEMIL RKVPMWLFPL AFHNDDNIKY YACLAIAVLV ANKEIEAEVL KSGCLDLVEP FVTSHDPSAF ARSNLAHAHG QSKHWLKRLV PVLSSNREEA RNLAAFHFCM EAGIKREQGN TDIFREINAI EALKNVASCP NAIASKFAAQ ALRLIGETVP HKLSQQVPLW SVEDVQEWVK QIGFNDYIDK FNESQVDGDL LLKLNQDNLR ADIGIGNGIL LKRFERELQN LKRMADYSSK DTAKMHQFLS EIGTDYCTYT YAMLNAGIDK CALPHVNEDM LMTECGIHNS IHRLRILNAV KNLENSLPSS SEENMAKTLD VFVSYRRSNG SQLASLLKVH LQLRGFSVFI DVERLEAGKF DNGLLNSIRQ AKNFVLVLTP DALHRCINDE DCKDWVHREI VAALNSNCNI IPIIDQQFDW PEVERLPEDM RSVAHFNGVN WIHDYQDACI DKLERFLRGE KNIDRIAAMV PGTPGSVSYQ RMHSNDSDYQ SGGAGAGSGA GTGGGGGGGV TGSVVDGLMV AANGSGQANH QANRYRQSPS PARQRGSTSQ LSGYSRAPSK RSQILTPYRT QQAALLHKTG AGSASMQNMM PLAYLPPRRS SAAGLGHGSG SGMGSGYRSH SVDGLLDQAG STPEQRIAAA AAKVTAGSTA LTNASSTSTL QPEEEVTDAA LNDSVTRRDK HTLSPPGNVQ QHRKSRSLDH ILSKQTLAEL LPPSSELADG TQSMQNLAIP MTPQPQRRDT SSSSKSPTPE RPPQPAMERV RERQSPEGVS ATESEREDQP EECLRHGNQQ RASASVHRGA SLTSNKTSNS SLGSNFSAGG NNKTIFNRTM KKVRSLIKKP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, it is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting axon destruction. Involved in the down-regulation of the tracheal immune response to Gram-negative bacteria. This is likely by mediating Tollo signaling in the tracheal epithelium.

Gene References into Functions

In Ect4 knockdown flies Drosophila C virus-induced mortality occurred more quickly and virus accumulation was increased. PMID:27960110
findings show that loss of dSarm (sterile alpha/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wallerian degeneration for weeks after axotomy; results provide direct evidence that axons actively promote their own destruction after injury PMID:22678360

Hide All

Subcellular Location

Cytoplasm. Cell projection, axon.

Tissue Specificity

Widely expressed in larval brains and adult brains.

Database Links

UNIGENE: Dm.5517

KEGG: dme:Dmel_CG43119

STRING: 7227.FBpp0293535

Promotions