Recombinant Drosophila melanogaster RAC serine/threonine-protein kinase (Akt1), partial

1. The metabolic defects of cycG mutant animals are abrogated by a concomitant loss of Wdb, CycG presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG mutants. PMID:26980713
2. The developmental delay of these novel Akt1 hypomorphs results in a latent phenotype uncovered by generation of somatic clones PMID:25889856
3. these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation PMID:25329475
4. Akt1 governs two critical elements of synapse development, neurotransmitter receptor localization, and postsynaptic membrane elaboration PMID:23592328
5. Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. PMID:22759636
6. Overexpression of Akt enhanced Sindbis virus replication. PMID:22258238
7. dAkt activation under wild-type conditions is defined by feedback inhibition that depends on TOR Complex 1 PMID:20585550
8. A mutation in the pleckstrin homology (PH) domain of Akt that reduces its affinity for PIP3 sufficed to rescue the lethality of flies devoid of PTEN activity. PMID:11872800
9. stimulates growth by phosphorylating the tuberous sclerosis complex 2 (Tsc2) tumour suppressor and inhibiting formation of a Tsc1-Tsc2 complex PMID:12172554
10. cell growth control by PTEN and it's ability to regulate known cell size regulators involved in protein translation (review) PMID:12367630
11. In Drosophila cells, Drosophila protein kinase B is required for the activation of Drosophila p70 ribosomal S6 protein kinase by insulin. PMID:12841848
12. InR regulates cell growth and proliferation through the dAkt pathway. PMID:12893776
13. Although S6K phosphorylation is independent of phosphoinositide 3-OH kinase (PI3K) and serine/threonine protein kinase Akt, that of 4E-BP is dependent on PI3K and Akt. PMID:14645523
14. results show show that target of rapamycin (TOR) kinase and its associated protein rictor are necessary for AKT/PKB Ser473 phosphorylation and that a reduction in rictor or drosophila TOR (dTOR) expression inhibited an Akt/PKB effector PMID:15718470
15. The characterization of synaptic long-term depression (LTD) at the Drosophila requires AKt protein. PMID:16611817
16. Ras-phosphatidylinositol 3-kinase (PI3K)-Akt activity in the peripheral glia promotes growth of the perineurial glia by inhibiting forkhead box O (FOXO). PMID:17215387
17. both AKT and HSP70 alleviated mHtt-induced toxicity in the retina. In contrast, their protective effects differed in the brain PMID:18065778
18. Akt regulates a complex containing Zw3, Armadillo, APC2, and EB1 and that this complex has a role in stabilizing MT-cortex interactions, facilitating both centrosome separation and mitotic spindle orientation. PMID:18268102
19. The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila PMID:18827008
20. shows that phosphorylation of the Tsc1/2 complex by Akt is not required for Akt to activate TORC1 and to promote tissue growth in Drosophila PMID:19609361

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UNIGENE: Dm.1219

KEGG: dme:Dmel_CG4006

STRING: 7227.FBpp0082682