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Recombinant Drosophila melanogaster Putative serine/threonine-protein kinase haspin homolog (Haspin), partial

Recombinant Drosophila melanogaster Putative serine/threonine-protein kinase haspin homolog (Haspin), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Haspin

Uniprot NO.

P83103

Alternative Names

Haspin; CG40080; Putative serine/threonine-protein kinase haspin homolog; EC 2.7.11.1

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-566

Target Protein Sequence

MLSISKTKMD FLEEGRWKDP FDELLDSRTK LSKMNIVKQN VRVTYNIDSS VENSSYIEIK EPNHKNEPLT LEDCSIKVYC PSDSISTPCD KRLGGTTGLF ETDLSPITRL KLEGVEDSRD KCADTNEADL YVNVEILFQN INSSPKKCSN FGKKRLSNLN KMVTAVHPSI SLNPGKWRKS LNNFIRSKIT ETNFTKKVER RSSICQDRKS LVLKGEHKFE NKYEEDVLKY CHQCTPLPFN TAYEQHKLLN TKKIGEGAYG EVFRCSRNQE VLKDHISDIV LKIIPLEGST VINGEKQKTF SQILPEIIIT KKMCSLRTSK TNSTNGFVSI QKVSLVKGRY PPHFIKLWEK YDNEKGSEND HPELFGDNQL FAVLELKFAG SDMANFKFLN SEQSYYALQQ IILALAVGEE EYQFEHRDLH LGNILIEYTN KKHIVCTFKS SNLTLLSKGV NVTIIDYTLS RVTINDCCYF NDLSRDEELF QATGDYQYDV YRMMRNELKN NWSSFSPKTN IIWLSYVIVK VLDSVKYKSI NTKVHRMYID KIKELKNIIM TFESASHCAN YLFNLN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-4' (H3T3ph) during mitosis and interphase. Function is essential for chromosome organization during mitosis and genome organization in interphase cells, thus playing a functional role in gene regulation. During mitosis, may act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. During interphase, associates with the cohesion complex and mediates pds5 binding to chromatin to ensure correct sister chromatid cohesion, chromatin organization, and also functions with Pds5-cohesin to modify Polycomb-dependent homeotic transformations. Function during interphase is required for insulator activity, nuclear compaction, heterochromatin-induced position-effect variegation and PcG-mediated pairing-sensitive silencing.

Subcellular Location

Nucleus lamina. Chromosome. Cytoplasm, cytoskeleton, spindle.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, Haspin subfamily

Database Links

UNIGENE: Dm.28538

KEGG: dme:Dmel_CG40080

STRING: 7227.FBpp0112507

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