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Recombinant Drosophila melanogaster Nuclear hormone receptor FTZ-F1 (ftz-f1), partial

Recombinant Drosophila melanogaster Nuclear hormone receptor FTZ-F1 (ftz-f1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ftz-f1

Uniprot NO.

P33244

Alternative Names

ftz-f1; NR5A3; CG4059Nuclear hormone receptor FTZ-F1; FTZ-F1 alpha; Nuclear receptor subfamily 5 group A member 3

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-1027

Target Protein Sequence

MDTFNVPMLA ESSNTNYATE ATSNHHHLQH QHQQQHSHQQ QQQQQLLMPH HHKDQMLAAG SSPMLPFYSH LQLQQKDATA TIGPAAAAAA VEAATTSANA DNFSSLQTID ASQLDGGISL SGLCDRFFVA SPNPHSNSNM TLMGTATAAT TTTTNNNNNN NTNNNNNNNV EAKTVRPSNG NSVIIESVTM PSFANILFPT HRSANECIDP ALLQKNPQNP NGNNSSIIVP PVEYHQLKPL EVNSSTSVST SNFLSSTTAQ LLDFEVQVGK DDGHISTTTT TGPGSGSASG SGSGSGSGSG SIARTIGTAT PTTTTSMSNT ANPTRSSLHS IEELAASSCA PRAASPNSNH TSSASTTPQQ QQQQQHHMQS GNHSGSNLSS DDESMSEDEF GLEIDDNGGY QDTTSSHSQQ SGGGGGGGGG NLLNGSSGGS SAGGGYMLLP QAASSSGNNG NPNAGHMSSG SVGNGSGGAG NGGAGGNSGP GNPMGGTSAT PGHGGEVIDF KHLFEELCPV CGDKVSGYHY GLLTCESCKG FFKRTVQNKK VYTCVAERSC HIDKTQRKRC PYCRFQKCLE VGMKLEAVRA DRMRGGRNKF GPMYKRDRAR KLQVMRQRQL ALQALRNSMG PDIKPTPISP GYQQAYPNMN IKQEIQIPQV SSLTQSPDSS PSPIAIALGQ VNASTGGVIA TPMNAGTGGS GGGGLNGPSS VGNGNSSNGS SNGNNNSSTG NGTSGGGGGN NAGGGGGGTN SNDGLHRNGG NGNSSCHEAG IGSLQNTADS KLCFDSGTHP SSTADALIEP LRVSPMIREF VQSIDDREWQ TQLFALLQKQ TYNQVEVDLF ELMCKVLDQN LFSQVDWARN TVFFKDLKVD DQMKLLQHSW SDMLVLDHLH HRIHNGLPDE TQLNNGQVFN LMSLGLLGVP QLGDYFNELQ NKLQDLKFDM GDYVCMKFLI LLNPSVRGIV NRKTVSEGHD NVQAALLDYT LTCYPSVNDK FRGLVNILPE IHAMAVRGED HLYTKHCAGS APTQTLLMEM LHAKRKG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.

Gene References into Functions

the alpha6 helix is dynamic in solution when Ftz-F1 is bound to the LxxLL motif of its cofactor Ftz, undergoing motions on the fast (picosecond to nanosecond) as well as slow (microsecond to millisecond) time scales. PMID:29547262
a novel ecdysone-dependent enhancer in the intron of ftz-f1 gene PMID:28726107
Comparative analysis of enhancers containing Ftz/Ftz-F1 binding sites that were or were not bona fide targets in vivo suggested that GAF negatively regulates enhancers that contain Ftz/Ftz-F1 binding sites but are not actually utilized. PMID:27723822
dATAC histone acetyltransferase complex is indispensable for the regulation of expression and probably for the stabilization of Ftz-F1, the main transcription regulator of Halloween genes. PMID:25959239
betaFTZ-F1 is expressed in most cells at the late pupal stage, under the control of ecdysteroids and plays important roles during pupal development. PMID:24611773
functional equivalence of ftz-f1 orthologs in these sensitive in vivo assays argues against specific activating ligands for NR5A family members PMID:23340581
ssFTZ-F1 is required for fat-body remodeling in Drosophila PMID:21978772
betaFTZ-F1 is a regulator for temporal gene expression at the onset of metamorphosis PMID:12392575
betaFTZ-F1 plays a role in regulating ecdysteroid titers during post-embryonic developmentby regulating Phantom protein and Disembodied protein expression. PMID:15936331
EDG84A gene encoding pupal cuticle protein is one of the targets of ecdysteroid-inducible transcription factor betaFTZ-F1; betaFTZ-F1 is expressed in almost all tissues. PMID:16025347
Serves as a molecular sign to guide the recruitment of ecdysone receptor/Ultraspiracle/FISC to 20-hydroxyecdysone-inducible target promoters. PMID:17015464
propose that pair-rule genes, exemplified by Ftz/Ftz-F1, promote segmentation by acting at different hierarchical levels, regulating segmentation and regulatory genes PMID:19679121
The Ftz-F1 DNA binding domain interacts strongly with Ftz and dramatically facilitates the binding of Ftz to target DNA. PMID:11520662