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Recombinant Drosophila melanogaster Methyltransferase-like protein 14 homolog (CG7818)

Recombinant Drosophila melanogaster Methyltransferase-like protein 14 homolog (CG7818)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

CG7818

Purity

>85% (SDS-PAGE)

Target Names

CG7818

Uniprot NO.

Q9VLP7

Alternative Names

Mettl14; KAR4; CG7818; N6-adenosine-methyltransferase non-catalytic subunit; Karyogamy protein 4; Methyltransferase-like protein 14; dMettl14

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-397

Target Protein Sequence

MSDVLKSSQE RSRKRRLLLA QTLGLSSVDD LKKALGNAED INSSRQLNSG GQREEEDGGA SSSKKTPNEI IYRDSSTFLK GTQSSNPHND YCQHFVDTGQ RPQNFIRDVG LADRFEEYPK LRELIKLKDK LIQDTASAPM YLKADLKSLD VKTLGAKFDV ILIEPPLEEY ARAAPSVATV GGAPRVFWNW DDILNLDVGE IAAHRSFVFL WCGSSEGLDM GRNCLKKWGF RRCEDICWIR TNINKPGHSK QLEPKAVFQR TKEHCLMGIK GTVRRSTDGD FIHANVDIDL IISEEEEFGS FEKPIEIFHI IEHFCLGRRR LHLFGRDSSI RPGWLTVGPE LTNSNFNSEL YQTYFAEAPA TGCTSRIELL RPKSPPPNSK VLRGRGRGFP RGRGRPR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Non-catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Ime4/Mettl3, Mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions.

Subcellular Location

Nucleus.

Protein Families

MT-A70-like family

Database Links

UNIGENE: Dm.351

KEGG: dme:Dmel_CG7818

STRING: 7227.FBpp0079219

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