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Recombinant Drosophila melanogaster E3 ubiquitin-protein ligase Bre1 (Bre1), partial

Recombinant Drosophila melanogaster E3 ubiquitin-protein ligase Bre1 (Bre1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Bre1

Purity

>85% (SDS-PAGE)

Target Names

Bre1

Uniprot NO.

Q9VRP9

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-1044

Target Protein Sequence

MSKRSADDAT GSSCLVAAAA AGQPPIKKVH FEPHLIGPVS TLEEMDIKVL EFQNKKLAQR IEQRMRTEAE LRHRIEQLEK RQTQDDAVLN VVNRYWNQLN EDIRVLLQRF DAETADELEN RNENEVTTSF LAQLSTWDKE ELDEKLANRV QVSKRAVAKI VQVIDRLMQR NEKITHVLKG DSLASAGSGS GAGAGGEEEQ QQASGDAETT TSSAGVHALE ETLKQTHIEI MSENHKLQNL NTSLHEKFHT MSLKMKEYQD AHTAKETENA ELKNQIDELQ YDLEKIHCRN DKLENHLAEA IEKLKAYHQI YGDPNKSTNS AKTPTTTGSG GATTSVNSQL LEELQKELEE YRELANNRLQ ELDKLHATHR ETLKEVEKLK MDIRQLPESV IVETTEYKCL QSQFSVLYNE SMQIKTMLDE TRNQLQTSKN QHLRQIEVME SEELIAQKKV RSEMIQMEDV LALIRKEYET LRIEFEQNMA ANEQTAPINR EMRHLITSLQ NHNGQLKGEV QRYKRKYKDT STDNLKLRQE LADALATLEG NKLQAATGAA GEEIKQENST GVKEENSNNV SASGQTNQTN SGNDTNVAIK EENHISAEDE ADDEASGKDV KDGIKQEKLS SGDAAAAEKK DSPGPGNSTS SATNSVPVKN EKDSKDGVKG KDVKAVESET VRDLKAQLKK ALNDQKEMKL LLDMYKGVSK DQRDKVQLMA TEKKLRSEIE ELRQQLKKLQ ESKREERKKL ADEEALRKIK QLEEQKYELQ KQMANHKPTD NSWGSGAPGT ANYTRPFVGS HEEEALLNEM EVTGQAFEDM QEQNSRLIQQ LREKDDANFK LMSERIKANQ LHKLLREEKT VLEDQMATAT TQIEAMHIVL RKLEEKERSL QATVASIEKE LMLRQQAMEM HKRKAIESAQ SAADLKLHLE KYHAQMKEAQ QVVAEKTSSL EAEAYKTKRL QEELAQFKRK AERMKKMEMS GTTIDEVMIE EIREYKETLT CPSCKVKRKD AVLSKCFHVF CYDCLRTRYE TRQRKCPKCN CAFGANDYHR LYLQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes.

Gene References into Functions

dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary. PMID:23624310

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Subcellular Location

Nucleus.

Protein Families

BRE1 family

Database Links

UNIGENE: Dm.855

KEGG: dme:Dmel_CG10542

STRING: 7227.FBpp0076822

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