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Recombinant Drosophila melanogaster Death domain-containing adapter protein BG4 (BG4)

Recombinant Drosophila melanogaster Death domain-containing adapter protein BG4 (BG4)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

BG4

Purity

>85% (SDS-PAGE)

Target Names

Fadd

Uniprot NO.

Q9V3B4

Alternative Names

Fadd; BG4; CG12297Fas-associated death domain protein; Death domain-containing adapter protein BG4; FAS-associating death domain-containing protein; dFADD

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-239

Target Protein Sequence

MTAGRHWSYD SLKQIAIDGC TENVEQLKLI FVEEIGSRRR SDCIRTIEDL IDCLERADEL SEYNVEPLRR ISGNMPQLIE ALSAYTKPEN ILGHPVNLYQ ELRLAEELRQ QLRIAPASQN AQPSVSELAA AVPPTAIQNY ATPAAFTDHK RTMVFKKISE ELGRYWRRLG RSAGIGEGQM DTIEERYPHD LKSQILRLLQ LIEEDDCHDP KHFLLRLCRA LGDCGRNDLR KRVEQIMSH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.

Gene References into Functions

demonstrate that dFADD is a novel component of the immune deficiency pathway; double-stranded RNA expression reduces the induction of antibacterial peptide-encoding genes after infection and renders the fly susceptible to Gram-negative bacterial infection PMID:12123572
dFADD acts downstream of IMD protein in the pathway that controls inducibility of the antibacterial peptide genes PMID:12433364

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Subcellular Location

Cytoplasm.

Database Links

UNIGENE: Dm.1273

KEGG: dme:Dmel_CG12297

STRING: 7227.FBpp0083574

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