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Recombinant Drosophila melanogaster DNA-binding protein D-ETS-6 (Ets21C)

Recombinant Drosophila melanogaster DNA-binding protein D-ETS-6 (Ets21C)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ets21C

Uniprot NO.

P29776

Alternative Names

Ets21C; ETS-6; CG2914DNA-binding protein D-ETS-6

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-475

Target Protein Sequence

MAILQNSRQS HKQLPIISQT IRSAWCQQRP INAMHQDVRQ KSIGSGNETK LEAKETEVPT NRRRRRRRCS SSSTSDSSAS SYSSTDSDSG SSTSSSSIRS QLPALNLPVP LPLATPTPPA VSSPHQAPSP RRNSSDSNRS VSPVEVPVDP HAWTPEDIAS WVRWATRKFK LDPEPDIDRF PKDAQELCDL SRADFWVCAG SRRGGMLLAQ HFAISLYHAT GRETSPMLND DEPNPYQLLN AASHRLVAQG SGGQIQLWQF LLELLADSSN ANAISWEGQS GEFRLIDPDE VARRWGERKA KPNMNYDKLS RALRYYYDKN IMTKVHGKRY AYKFDFHGLM AACQAQAQGG DPASSMLGSY NHHAGGAMQL GRHPPPLHHH PQHSHPHHQL GQPHFLHPHH SSPASNSSSL GFPSSSTASS QASPGQAPAS SSASTSNFTA PFQGGTAGVD PARTSTSSAG NYDQGPVTPT TNAFN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Gene References into Functions

Data show that Ets21C has a crucial role in the regulation of tumor growth as a loss of function critically reduced tumor growth, whereas an excess of Ets21C further increased tumor size. While Ets21C was shown only with a role in fine-tuning the transcriptional program of neoplastic tumors, results point towards a more fundamental role as activator of a specific set of target genes driving tumor growth and invasion. PMID:27713480
malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS-domain factor Ets21c and the nuclear receptor Ftz-F1, all acting downstream of Jun-N-terminal kinase. PMID:26398940
These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila Intestinal Stem Cells PMID:26683696

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Subcellular Location

Nucleus.

Protein Families

ETS family

Tissue Specificity

Embryonic ventral nervous system and 1 pair of neurons in each thoracic segment.

Database Links

UNIGENE: Dm.21518

KEGG: dme:Dmel_CG2914

STRING: 7227.FBpp0077739

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