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Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1 (Chd1), partial

Recombinant Drosophila melanogaster Chromodomain-helicase-DNA-binding protein 1 (Chd1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Chd1

Purity

>85% (SDS-PAGE)

Target Names

Chd1

Uniprot NO.

Q7KU24

Alternative Names

Chd1; CG3733; Chromodomain-helicase-DNA-binding protein 1; CHD-1; EC 3.6.4.12; ATP-dependent helicase Chd1

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-1883

Target Protein Sequence

MSQALNESAN SIGSDEQDDT REEANGTDHS GSGSGSGSSG SDSDSDSSSG NSSDGRSSPE PEDKSLSVAG FPPTAAAAQA DSKTNGFTDD QEDSSSDGSS GSDSDSDAEG PSDQRNQSIN NANTSSSLPK PEQNEEEDNE TEAGQQQPAS DASADESSDS SANVSPTSSS SSSEEEEEDY RPKRTRQARK PPTAAEKSKK APAPKNKKKT WDSDESDESE DSDDEVSTAQ KRKPAATTSR SKLAQQQQRR RVKPFSSEDS DDDDASKRCA TRRKGAAVSY KEASEDEATD SEDLLEFEYD ESQAATTAAT AEEEEKCETI ERILAQRAGK RGCTGNQTTI YAIEENGFDP HAGFDEKQTP DAETEAQFLI KWKGWSYIHN TWESEATLRD MKAKGMKKLD NFIKKEKEQA YWRRYAGPED IDYFECQLEL QHELLKSYNN VDRIIAKGSK PDDGTEEYLC KWQSLPYAES TWEDAALVLR KWQRCAEQFN DRESSKCTPS RHCRVIKYRP KFSRIKNQPE FLSSGLTLRD YQMDGLNWLL HSWCKENSVI LADEMGLGKT IQTICFLYSL FKIHHLYGPF LCVVPLSTMT AWQREFDLWA PDMNVVTYLG DIKSRELIQQ YEWQFESSKR LKFNCILTTY EIVLKDKQFL GTLQWAALLV DEAHRLKNDD SLLYKSLKEF DTNHRLLITG TPLQNSLKEL WALLHFIMPD KFDTWENFEV QHGNAEDKGY TRLHQQLEPY ILRRVKKDVE KSLPAKVEQI LRVEMTSLQK QYYKWILTKN FDALRKGKRG STSTFLNIVI ELKKCCNHAA LIRPSEFELM GLQQDEALQT LLKGSGKLVL LDKLLCRLKE TGHRVLIFSQ MVRMLDVLAD YLQKRHFPFQ RLDGSIKGEM RRQALDHFNA EGSQDFCFLL STRAGGLGIN LATADTVIIF DSDWNPQNDL QAQARAHRIG QKNQVNIYRL VTARSVEEQI VERAKQKMVL DHLVIQRMDT TGRTVLDKSG NGHSSNSNPF NKDDLSAILK FGAEELFKDE QEHDDDLVCD IDEILRRAET RNEDPEMPAD DLLSAFKVAS IAAFEEEPSD SVSKQDQNAA GEEDDSKDWD DIIPEGFRKA IDDQERAKEM EDLYLPPRRK TAANQNEGKR GAGKGGKGKQ QADDSGGDSD YELGSDGSGD DGRPRKRGRP TMKEKITGFT DAELRRFIRS YKKFPAPLHR MEAIACDAEL QEKPLAELKR LGEMLHDRCV QFLHEHKEEE SKTAATDETP GAKQRRARAT FSVKLGGVSF NAKKLLACEQ ELQPLNEIMP SMPEERQQWS FNIKTRAPVF DVDWGIEEDT KLLCGIYQYG IGSWEQMKLD PTLKLTDKIL LNDTRKPQAK QLQTRAEYLL KIIKKNVELT KGGQRRQRRP RASRANDAKA ASQSASSTID AKPHDGEDAA GDARTVAESS NSQVDPSTAS PHNAPATEQH GDPAKKAKKS KARSKKTSAS DNNGNKPMHF TANNEPRALE VLGDLDPSIF NECKEKMRPV KKALKALDQP DVSLSDQDQL QHTRDCLLQI GKQIDVCLNP YAETEKKEWR SNLWYFVSKF TELDAKRLFK IYKHALKQKA GGDGEAKGKD KGSSGSPAKS KPNGVTTEEK EKERDRSGGK KKKKDKDKER SGQARYPETG IPTSGRYADP PLKRKRDEND ADASSGLAGA PGGGIGDNLK SMSFKRLNMD RHEDRKKHHR GPDYYGGSGP PMGSGSYEGG SNSRRQGPTS PSTPRTGRGG YDPPPAPSGY TPEMERWQSR DRYSQDYKRD RYDGYGRSGG GQGSYHRERD RRPEKRRYPS GLPPHPYSSH YLPPNYYGLP NGAVPGLPPP SSVYRSDPRG YPVMPRDYPA DYRRSDYERR TQT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome. Involved in assembly of active chromatin. Required for maintaining open chromatin and pluripotency in embryonic stem cells and is important for wing development and fertility. Is essential for the incorporation of histone H3.3 and assembly of paternal chromatin. Required for replication-independent nucleosome assembly in the decondensing male pronucleus.

Gene References into Functions

An effect of Chd1 null mutation can be increased by deficiency of one of the genes, encoding variant histone H3.3, His 3.3 B, suggesting that the role of CHD1 in the control of male X chromosome organization can be mediated by CHD1 activity in H3.3 histone deposition and exchange. PMID:30191695
The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2. PMID:23533627
Intestinal resistance against infection by P. aeruginosa is linked to maintaining proper balance of gut-microbe interactions and the chromatin remodeler CHD1 is involved in regulating this aspect. PMID:22912810
our results emphasize a role for Chd1 in histone replacement in both budding yeast and Drosophila melanogaster, and surprisingly they show that the major effects of Chd1 on turnover occur at the 3' ends of genes. PMID:22807688
results suggest a role for CHD1 in the assembly of active chromatin and a function of ACF in the assembly of repressive chromatin PMID:15643425
findings establish CHD1 as a major factor in replacement histone metabolism in the nucleus and reveal a critical role for CHD1 in the earliest developmental instances of genome-scale, replication-independent nucleosome assembly. PMID:17717186
These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function. PMID:18202396