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Recombinant Drosophila melanogaster Breast cancer type 2 susceptibility protein homolog (Brca2), partial

Recombinant Drosophila melanogaster Breast cancer type 2 susceptibility protein homolog (Brca2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Brca2

Purity

>85% (SDS-PAGE)

Target Names

Brca2

Uniprot NO.

Q9W157

Alternative Names

Brca2; CG30169; Breast cancer type 2 susceptibility protein homolog; dmbrca2

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-971

Target Protein Sequence

MDQNGASGSH PNRLSQGRGA HARERGATVS AAANRSNIID EMAKICEADR QTFAIARRTR GHERLAVDNS DFVAVEDLIL SYAEPTPEDQ VEMIMSDFCS SPTYAEDEDE PSHESEPWFR FRNKRIRTYS RKRDPKSHKA VQNEKRRGSS GLSVQRDLNT SFTSMACDFD ASSQKIHEVL LNLSQYFSAT ATASGPTPVP SQIDLPTEAR QDSGDECFNA ELENLRDDLL QSGFTFEASF YENEHEQEGP GTMADTIYGD SMQSVPTTRL RLESGKRNVW SDADSTLKKA DVEIAENKKL LMGQTQAKNV DIEENTNFIL EGIPLSEWLT PMELPEISKD VIKHIPDKKL KLEPSSQKEQ KSSKDSNASK VRGASKQSCD INTKNEGTTI LDQPNAAEQE NLLNDGELLE EFLFNDWQPM QCSNGPSTSK NAIQGPKENI NSINLDDKEQ PEKQTPNKSQ TISSHQLNGI RKKSFKFIEV SEEMKIKGEE FVDKVVSGLY HFSHKCNLRT EEYSDNHSQV MESTQCAEFK SAPSKPIEIL DGKETYNAIA KVDVGEINGK FSPLNNDTIA EPEFCGFRTA SNKAIPISEK MKIKTAEFMA EFQSKETIQQ NDYLVHQPND KPTSVGLDTA LKRSIESSEE MRSKASKLVV VDTTMREPHQ PTLDPVCRDL NESQFFGFRT ASNKAIEITE AMEKRGAMFL AQSKATDQLN GWQPSDFPDV LPTSPNNEIH SINVENNKAV NTKTVSETEF FGFRTASNKG IVISENTKIK VAQFMSEFQA ADASTDSNQP TVISEESRNI DAKFVDEAAA EDSANKPTFC NVQSLKNTSD IEHFKHDFFV EHSAKEEHPL CSQPLVRTPR RSQEIHSSLS QLAGKSPLDQ ATKKSVIARR NLLSLKRKRK IILSTETSTS CALPTMERFA PKPSSTSTPL ADRDLNRSKD CTKNRQDAED MSPICMQPKK SRRLGLSRSR Y
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint.

Gene References into Functions

A mutation in Cyp6d2, a cytochrome P450 gene, when combined with a brca2 mutation, resulted in synergistic hypersensitivity to camptothecin. PMID:23316441
DNA repair by homologous recombination is dramatically decreased in CG30169 (brca2 homolog) mutants. PMID:18266476

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Subcellular Location

Nucleus.

Database Links

UNIGENE: Dm.13825

KEGG: dme:Dmel_CG30169

STRING: 7227.FBpp0072209

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