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Recombinant Drosophila melanogaster Brain tumor protein (brat), partial

Recombinant Drosophila melanogaster Brain tumor protein (brat), partial

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

brat

Purity

>85% (SDS-PAGE)

Target Names

brat

Uniprot NO.

Q8MQJ9

Alternative Names

brat; CG10719Brain tumor protein

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-1037

Target Protein Sequence

MASSPTPSLD SMRGGANSIE SYEHAGYLSD SPLTLSGSSP PASDSAICSD EYTGGSSVKS RSEVTVINGH HPISASVSSS SSASSSSCSS SSSSSSSSSS SSSSTSGLSG CGSTSSSVIS ANNVASSNGP GVIGSNLQSS NNGGNSGISS LVVGAGKGSN SSSNSSSSNT SANGSPPRCT ACKSKCSDAV AKCFECQSYL CANCVTAHEF MHCFNGHNVC LIKGFEASTT GTPLSVGSPS NNPASNEFKY ASSLTMMLQQ QQQLDSQQQQ QQQQLLPAQP MSQLSKIVLA AAAQANSQEQ QREDSIYGSL HPQQQQQQQQ QQQRQLFCPR HKQELLKFSC RTCCILVCKE CIVLEHSTGL HELENVQSPG MTTSTGSTAN ESALQTLLAD MRGKIGEIVG IAGNSDQNLT KVKLQYQKAH NELNETHQFF ASMLDERKTE LLKELETLYT AKVNSNNSWQ QRSRDLIDKG LATCEAVERS PAPPSSLLTE ALLLRKSLEQ QLQTGIQEMQ LPFEIEFMSN YQSIQAGVRN TFGYIRANSS DGGPTGMSLT SNGHGKQPPI ARPTQSASNS SASSAGSGHH GHHQQSHHHG HHNHHQTAHH QQLQAQSSLH GLGLGLSGAS LLDSSSSAGG AVGAFSNGGL LLGGRDRNAL AVEQHFGELM PKRGGGGYTG SNGSATSAVA HYNPYEKWSN GGSDNLFSSV TSGVSGSSAV ADAFASLSAV GGSVVSGAGA GGSTVSSESL LDLTNKLLSA TIYPPKSQIK RQKMIYHCKF GEFGVMEGQF TEPSGVAVNA QNDIIVADTN NHRIQIFDKE GRFKFQFGEC GKRDSQLLYP NRVAVVRNSG DIIVTERSPT HQIQIYNQYG QFVRKFGATI LQHPRGVTVD NKGRIIVVEC KVMRVIIFDQ NGNVLHKFGC SKHLEFPNGV VVNDKQEIFI SDNRAHCVKV FNYEGQYLRQ IGGEGITNYP IGVGINSNGE ILIADNHNNF NLTIFTQDGQ LISALESKVK HAQCFDVALM DDGSVVLASK DYRLYIYRYV QLAPVGM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

A NHL-domain family protein that functions a translational repressor to inhibit cell proliferation. Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. During neuroblast division, segregates asymmetrically and inhibits self-renewal of one of the two daughter cells. Together with the asymmetrically segregating transcription factor prospero ensures that the daughter cell will stop growing, exit the cell cycle, and differentiate into neurons possibly by modulating the function of dm in ganglion mother cells (GMC). Restrics developmental potential of type II intermediary neuronal progenitor (INP) cells playing a role in proliferation and maturation of the neuroblasts.

Gene References into Functions

Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor proteins has been described. PMID:28318367
Data suggest that brain tumor protein (Brat) promotes midline crossing through directing the localization or stability of Adenomatous polyposis coli-2 (Apc2) at the plus ends of microtubules in navigating commissural axons. PMID:29617376
results support a novel role for Brat/TRIM3 in maintaining stem cell equilibrium and suppressing tumor growth by regulating NICD nuclear transport PMID:26893479
BRAT is a prominent post-transcriptional regulator in the early embryo through mechanisms that are largely independent of PUM. PMID:25962635
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction PMID:25297111
the Brat-dependent mechanism extinguishes the function of the self-renewal factor Klu in the presumptive intermediate progenitor cell by attenuating Arm activity, balancing stem cell maintenance and progenitor cell specification. PMID:24257623
These results together reveal an important and previously unidentified role for Brat in synaptic development and endocytosis mediated by suppression of BMP signaling. PMID:23884941
Cofactors Brain Tumor and eIF4E Homologous Protein are not obligatory for Pumilio and Nanos activity. PMID:22064486
Brain Tumor (Brat) was identified as a potent differentiation factor and target of Pum-Nos regulation. PMID:21238926
We show that Drosophila larval neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell. PMID:16564014
Results suggest that the tumour suppressor brat negatively regulates cell proliferation during larval brain development in Drosophila, and that Prospero acts as a key downstream effector of brat in cell fate specification and proliferation control. PMID:16774999

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Subcellular Location

Cytoplasm. Cytoplasm, cell cortex.

Tissue Specificity

Expressed during embryogenesis, mainly in nervous tissues. Expressed in the embryonic central and peripheral nervous systems including the embryonic brain. In third instar larva it is expressed in the larval central nervous system including the brain and

Database Links

UNIGENE: Dm.6426

KEGG: dme:Dmel_CG10719

STRING: 7227.FBpp0293081

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