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Recombinant Drosophila melanogaster Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase (sfl), partial

Recombinant Drosophila melanogaster Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase (sfl), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details

Abbreviation

sfl

Purity

>85% (SDS-PAGE)

Target Names

sfl

Uniprot NO.

Q9V3L1

Alternative Names

sfl; CG8339; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase; EC 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase; Sulfateless) [Includes: Heparan sulfate N-deacetylase; EC 3.-.-.-); Heparan sulfate N-sulfotransferase; EC 2.8.2.-)]

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in diffusion of morphogen wingless (wg) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of wg morphogens. Required for wg signaling during both embryonic and imaginal disk development. Also required for FGF receptor signaling.

Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Sulfotransferase 1 family, NDST subfamily

Database Links

UNIGENE: Dm.4995

KEGG: dme:Dmel_CG8339

STRING: 7227.FBpp0076677

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