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Recombinant Dog X-linked retinitis pigmentosa GTPase regulator (RPGR), partial

Recombinant Dog X-linked retinitis pigmentosa GTPase regulator (RPGR), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

RPGR

Purity

>85% (SDS-PAGE)

Target Names

RPGR

Uniprot NO.

Q9N1T2

Alternative Names

RPGR; X-linked retinitis pigmentosa GTPase regulator

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

1-1000

Target Protein Sequence

MGEPEEVMPG SGAVFTFGKT QFAENIPSKF WFRNDVPTFL SCGDEHTAVV TGNNKLYMFG SNNWGQLGLG SKSTVSKPTC VKALKPEKVK FAACGRNHTL VSTEGGKVYA AGGNNEGQLG LGDTEERSTF HLISFFTSQR KIKQLSAGSN TSAALTEDGE LFMWGDNSEG QIGLENVTNV CVPQQVTVGK PISWISCGYY HSAFVTTEGQ LYTFGEPECG KLGLPNQLLV NHRMPQPVPG IPGKVVQVAC GGGHTVVLTE KAVYTFGLGQ FGQLGLGTFL FETSVPKAIE HIKDQKISFI ACGENHTALI TDMGLMYTFG DGRHGKLGLG LENSTNQFIP TLCSNFLRFI VQLVSCGGCH TLVFATPRLG GTEEMELKEI NKSCFSAATS LSLSNLSSGI VLHQTLSARV RRREREKSPD SFQMTRTLPP IDGIPMPPVC FSPSPIPFYM AASNWSGKMT PEKEGLTQPE PDYFRDNMAK GKETDNSSAT DSESLGETTD VLNMTHMMSL NSNDKSLKLS PIDKQKKQET IEKLKQHTAH FGNDDSKGCA SEEMSKTVKE GKAYKQLLAK GIYMTQAAMT MEAFSDEDIG NDSGQPGPRA DTHAEGVQRK IFSCESKHGL YPPDFKAIAK ESDGGQSQKD PEAEETVSEK ENELAEMAGL QARRQSEENL RNINMFFDDL PNRDVNIEDE ESKDFVKDSR RNKQDVIFDS ERESIEEPDS YLEGESESQQ GTTDGFEQPE SVEFSSGEKE DDDEVETDQN LWYSRKFIEQ GHKEETEHIL SKFMAKYDFK CDHLSEIPEE QEGAEDSEGS GIEEQEVEAN ENVEVPAGKE EKEIEILSDD LTDRAEDHEF SEDEEPEDMA EELDEDLESK KNVPADVASD NSLKKDETTK QEKRAICEYN ENPKGNMHYH AKSSSSEVLN DSESTPNKDV KKSKKIFLFK RMSLMSQKSM QSNNEPLPEI KPIGDQIAFK GNKKDANQNH MGQNHQDTSP PDMERRSKSC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes.

Gene References into Functions

Lack of association between haplotypes and the disease phenotype suggests that these genes are not genetic modifiers of XLPRA1 PMID:27122963
a chromosome inversion disrupting the DMD and RPGR genes is the causative mutation for X-linked muscular dystrophy in the Japanese Spitz breed PMID:25644216

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Subcellular Location

Golgi apparatus. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Tissue Specificity

Isoform 1 is expressed exclusively in testis. Isoforms 2, 3 and 4 are widely expressed.

Database Links

UNIGENE: Cfa.3592

KEGG: cfa:403726

STRING: 9615.ENSCAFP00000037530

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