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Recombinant Dog Troponin I, cardiac muscle (TNNI3)

Recombinant Dog Troponin I, cardiac muscle (TNNI3)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

TNNI3

Purity

>85% (SDS-PAGE)

Target Names

TNNI3

Uniprot NO.

Q8MKD5

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

2-211

Target Protein Sequence

ADESGDAAG CPPPAPAPIR RQSSANYRAY ATEPHAKKKS KISASRKLQL KTLMLQIAKQ ELEREAEERR GEKGRALSTR CQPLELAGLG FAELQDLCRQ LHARVDKVDE ERYDVEAKVT KNITEIADLT QKIFDLRGKF KRPTLRRVRI SADAMMQALL GTRAKESLDL RAHLKQVKKE DTEKENREVG DWRKNIDALS GMEGRKKKFE G
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Gene References into Functions

No statistical differences were found between CRP and cTnI levels, either before or after surgical correction of brachycephaly in dogs. PMID:25673910
The objective of this study was to evaluate the correlation between anatomical components, clinical signs and several biomarkers, used to determine systemic inflammation and myocardial damage in dogs with brachycephalic upper airway obstructive syndrome. PMID:22937913
The use of NT-pro-BNP and troponin I levels as prognostic indicators for canine heart failure is reported. PMID:22439324
[NT-proBNP] concentration is significantly higher in dogs with pre-capillary pulmonary hypertension (PH) when compared to dogs with respiratory disease without PH; [NT-proANP] and [cTnI] were not elevated in dogs with pre-capillary PH. PMID:21835711
Moderate exercise does not present a confounding variable in the interpretation of cardiac tropinin I and C-reactive protein concentrations in normal dogs. PMID:20840303
Serum troponin I is high in dogs with either precapillary and postcapillary pulmonary hypertension (PH); myocardial damage in dogs with postcapillary PH is likely the consequence of increased mitral valve disease severity. PMID:20002552
Analysis of troponin I concentration has potential to increase knowledge of overall cardiac remodeling in dogs with mitral valve disease; the effect of age on troponin I levels should be considered in these patients. PMID:20002554
Circulating cTnI and pro-matrix metallopeptidase 9 increase in proportion to the severity of acute pulmonary thromboembolism PMID:18047836
The incidence of myocardial injury due to ehrlichiosis, as demonstrated by elevated cardiac troponin I blood levels, is reported. PMID:18638021