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Recombinant Dog Telomerase reverse transcriptase (TERT), partial

Recombinant Dog Telomerase reverse transcriptase (TERT), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

TERT

Purity

>85% (SDS-PAGE)

Target Names

TERT

Uniprot NO.

Q6A548

Alternative Names

TERT; Telomerase reverse transcriptase; EC 2.7.7.49; Telomerase catalytic subunit

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

1-1123

Target Protein Sequence

MPRAPRCRAV RALLRGRYRE VLPLATFLRR LGPPGRLLVR RGDPAAFRAL VAQCLVCVPW GARPPPAAPC FRQVSCLKEL VARVVQRLCE RGARNVLAFG FALLDGARGG PPVAFTTSVR SYLPNTVTET LRGSGAWGLL LRRVGDDVLT HLLARCALYL LVAPSCAYQV CGPPLYDLCA PASLPLPAPG LPGLPGLPGL GAGAGASADL RPTRQAQNSG ARRRRGSPGS GVPLAKRPRR SVASEPERGA HRSFPRAQQP PVSEAPAVTP AVAASPAASW EGGPPGTRPT TPAWHPYPGP QGVPHDPAHP ETKRFLYCSG GRERLRPSFL LSALPPTLSG ARKLVETIFL GSAPQKPGAA RRMRRLPARY WRMRPLFQEL LGNHARCPYR ALLRTHCPLR AMAAKEGSGN QAHRGVGICP LERPVAAPQE QTDSTRLVQL LRQHSSPWQV YAFLRACLCW LVPTGLWGSR HNQRRFLRNV KKFISLGKHA KLSLQELTWK MKVRDCTWLH GNPGACCVPA AEHRRREEIL ARFLVLVDGH IYVVKLLRSF FYVTETTFQK NRLFFYRKSV WSQLQSIGIR QLFNSVHLRE LSEAEVRRHR EARPALLTSR LRFLPKPSGL RPIVNMDYIM GARTFHRDKK VQHLTSQLKT LFSVLNYERA RRPSLLGASM LGMDDIHRAW RTFVLRIRAQ NPAPQLYFVK VDVTGAYDAL PQDRLVEVIA NVIRPQESTY CVRHYAVVQR TARGHVRKAF KRHVSTFADL QPYMRQFVER LQETSLLRDA VVIEQSSSLN EAGSSLFHLF LRLVHNHVVR IGGKSYIQCQ GVPQGSILST LLCSLCYGDM ERRLFPGIEQ DGVLLRLVDD FLLVTPHLTQ AQAFLRTLVK GVPEYGCRAN LQKTAVNFPV EDGALGSAAP LQLPAHCLFP WCGLLLDTRT LEVSCDYSSY AHTSIRASLT FSQGAKPGRN MRRKLLAVLR LKCCALFLDL QVNGIHTVYM NVYKIFLLQA YRFHACVLQL PFNQPVRKNP SFFLRVIADT ASCCYSLLKA RNAGLSLGAK GASGLFPSEA ARWLCLHAFL LKLAHHSGTY RCLLGALQAA KAHLSRQLPR GTLAALEAAA DPSLTADFKT ILD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

Gene References into Functions

This study evaluated the relationship between polymorphisms of Telomerase Reverse Transcriptase and the longevity and cancer susceptibility of 4 dog breeds. PMID:24423165
This study reports that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. PMID:21062413
Dog TERT shows the highest level of sequence similarity to the human TERT protein, supporting the dog as a model system for telomerase-based studies. PMID:15225880
Localization of catalytic subunit of telomerase reverse transcriptase in normal lens epithelial cells(LEC)corresponded with LEC's regional functions. (Catalytic subunit of telomerase reverse transcriptase) PMID:17093391
A higher expression of TERT was noted in canine and feline meningionas. PMID:17519562
These findings suggest that telomerase may be a valuable target for canine osteosarcoma (OSA) therapy, and that telomerase status does not appear to be a prognostic factor in canine OSA. PMID:18761602
DNA sequencing revealed two insertions (175 and 28 bp long) and two deletions (17 and 32 bp long), which were encountered in different combinations and gave rise to five different transcripts. PMID:18836773
TERT interacted with ERalpha via the estrogen response element (ERE) in cataractous lens epithelial cells (LEC) but not in normal LEC. PMID:19936027