Recombinant Dog Renin (REN)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

REN

Purity

>85% (SDS-PAGE)

Target Names

REN

Uniprot NO.

Q6DYE7

Alternative Names

REN; Renin; EC 3.4.23.15; Angiotensinogenase

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

66-403

Target Protein Sequence

LSSGN STSPVVLTNY LDTQYYGEIG IGTPPQTFKV VFDTGSANLW VPSTRCSPLY TACEIHCLYD SSESSSYMEN GTTFTIRYGS GKVKGFLSQD MVTVGGITVT QTFGEVTELP LIPFMLAKFD GVLGMGFPAQ AVGGVTPVFD HILSQGVLKE EVFSVYYSRN SHLLGGEVVL GGSDPQYYQG NFHYVSISKT GSWQIKMKGV SVRSATLVCE EGCMVVVDTG ASYISGPTSS LRLLMDTLGA QELSTNEYVV NCNQVPTLPD ISFHLGGRAY TLTSKDYVLQ DPYGNEDLCT LALHGLDVPP PTGPVWVLGA SFIRKFYTEF DRHNNRIGFA LAR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Gene References into Functions

With a moderate deficit in total body sodium and total body water, the renin-angiotensin-aldosterone system is the major factor controlling arterial blood pressure. PMID:19930429
Characterization of canine renin with mutations in the substrate binding site. PMID:17942478
Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta1-receptor blockade. PMID:19073902

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Subcellular Location

Secreted. Membrane.

Protein Families

Peptidase A1 family

Database Links

UNIGENE: Cfa.3701

KEGG: cfa:403838

STRING: 9615.ENSCAFP00000014146

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