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Recombinant Dog Progesterone receptor (PGR), partial

Recombinant Dog Progesterone receptor (PGR), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

PGR

Purity

>85% (SDS-PAGE)

Target Names

PGR

Uniprot NO.

Q9GLW0

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

1-939

Target Protein Sequence

MTERTGKDAR APHVAGGAPS PAPAAEPESR RRDGGRLRAS QTSDAPRVAA AAAAAAAAAS AAPSAPSDRL LFSRRGQGAD PGGKAQDAQP RPDVARADPR LEAASGAGAD SPGPPRQDRG PLHGAPSTAL RPAGPGQGRS SPAWEPRSPR CPSGPEPPED PRGARSSQGA ACPLMSRPEG KAGDGCGTAG AHKGPPRGLS PSRQPLPLCP GAHAWPGAAG KAATQPAALG VEDEGGFAAE GSPGPLLKGK PRPPAGPAAA AGAAPAAPGT APGGTAPVPK EDSRLPAPKG SLAEQDAPAP GCSPLATTMM DFIHVPILPL GSAFLAARTR QLLEAETYDA GAFAPPRGSP SAPCAPLAAG DFPDCAYPSD AEPKDDAFPL YGDFQPPALK IKEEEEGAEA AARSPRPYLA AGPHSCVFAD APPALPALPP LPPRAPSSRP GEGAPAAAAA AGCSASSASS PGPALECVLY KAEGAPPPQG PFAAAPCRVP GAGACLLPRD GAAAAASAGA AGASPALYQP LGLGALPQLG YQAAVLKEGL PQVYQPYLNY LRPDSDASQS PQYSFESLPQ KICLICGDEA SGCHYGVLTC GSCKVFFKRA MEGQHNYLCA GRNDCIVDKI RRKNCPACRL RKCCQAGMVL GGRKFKKFNK VRVMRTLDAV ALPQPVGIPN ESQALSQRIS FSPSQDIQLI PPLINLLMSI EPDVIYAGHD NTKPDTSSSL LTSLNQLGER QLLSVVKWSK SLPGFRNLHI DDQITLIQYS WMSLMVFGLG WRSYKHVSGQ MLYFAPDLIL NEQRMKESSF YSLCLTMWQI PQEFVKLQVS QEEFLCMKVL LLLNTIPLEG LRSQNQFEEM RSSYIRELIK AIGLRQKGVV SSSQRFYQLT KLLDNLHDLV KQLHLYCLNT FIQSRALSVE FPEMMSEVIA AQLPKILAGM VKPLLFHKK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.; Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.; Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.

Gene References into Functions

Marginal activity of progesterone receptor B in dogs but high incidence of mammary cancer PMID:25158022
ER, PgR and E-cadherin are expressed in canine mammary gland columnar cell lesions; cytokeratin 34betaE-12, HER-2 and P53 are not expressed PMID:20178635
The roles of leukemia inhibitory factor and progesterone receptor expression on the establishment and maintenance of canine pregnancy are reported. PMID:19754547
It was found that canine oocytes express estrogen receptor alpha and estrogen receptor beta throughout the oestrous cycle, however, there is a lack of progesterone receptor expression in all these phases. PMID:19754577
In bitches no significant variation in PR expression was observed between normal tissue, dysplasias, and benign neoplasms, but was significantly lower in mammary carcinomas PMID:16054892