Recombinant Dog Interleukin-13 (IL13) is a semi-custom product. There are 5 expression system options: Yeast, E. coli, In Vivo Biotinylation in E. coli, Baculovirus, and Mammalian cell. Your requirements will be given top priority in determining the protein tags. For proteins within 800 aa, risk-free custom service is guaranteed. It means you will not be charged if the protein cannot be delivered.
IL13 is a multifunctional cytokine involved in energy metabolism, inflammation, cancer, and allergic diseases. It regulates energy expenditure, thermogenesis, and mitochondrial biogenesis [1]. IL13 has been reported to target hepatic glucose production through a non-canonical downstream pathway involving IL13RA1/STAT3, indicating its role beyond inflammation regulation [2]. IL13 is a major effector of Th2 inflammation and tissue remodeling, indicating its significance in immune responses and inflammatory processes [3]. Genetic variations in the IL13 gene have been associated with susceptibility to asthma and atopic phenotypes in different populations [4]. IL13 has also been implicated in cancer, with studies showing its expression in Hodgkin lymphoma cells and its role in promoting neoplastic cell survival in mycosis fungoides [5][6].
References:
[1] M. García, P. Pazos, L. Lima, & C. Dieguez, Regulation of energy expenditure and brown/beige thermogenic activity by interleukins: new roles for old actors, International Journal of Molecular Sciences, vol. 19, no. 9, p. 2569, 2018. https://doi.org/10.3390/ijms19092569
[2] C. Ober and S. Hoffjan, Asthma genetics 2006: the long and winding road to gene discovery, Genes and Immunity, vol. 7, no. 2, p. 95-100, 2006. https://doi.org/10.1038/sj.gene.6364284
[3] K. Ådjers, A. Luukkainen, J. Pekkanen, M. Hurme, R. Renkonen, D. Wanget al., Self-reported allergic rhinitis and/or allergic conjunctivitis associate with <b><i>il13</i></b> rs20541 polymorphism in finnish adult asthma patients, International Archives of Allergy and Immunology, vol. 172, no. 2, p. 123-128, 2017. https://doi.org/10.1159/000456009
[4] K. Urayama, R. Jarrett, H. Hjalgrim, A. Diepstra, Y. Kamatani, A. Chabrieret al., Genome-wide association study of classical hodgkin lymphoma and epstein–barr virus status–defined subgroups, Jnci Journal of the National Cancer Institute, vol. 104, no. 3, p. 240-253, 2012. https://doi.org/10.1093/jnci/djr516
[5] P. Vieyra-Garcia, T. Wei, D. Naym, S. Fredholm, R. Fink‐Puches, L. Cerroniet al., Stat3/5-dependent il9 overexpression contributes to neoplastic cell survival in mycosis fungoides, Clinical Cancer Research, vol. 22, no. 13, p. 3328-3339, 2016. https://doi.org/10.1158/1078-0432.ccr-15-1784
[6] D. Blon, C. Guglielmetti, C. Hoornaert, A. Quarta, J. Daans, D. Dooleyet al., Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model, Journal of Neuroinflammation, vol. 13, no. 1, 2016. https://doi.org/10.1186/s12974-016-0756-7
