Home
Product
Protein
Recombinant Proteins
Recombinant Dog Insulin-like growth factor I (IGF1)

Recombinant Dog Insulin-like growth factor I (IGF1)

Code
MSDS	MSDS
Size	Pls inquire
Source
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

IGF1

Uniprot NO.

P33712

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

49-118

Target Protein Sequence

GP ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSA

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.

Gene References into Functions

This study suggested that serum 26SP concentrations seem to be increased in some dogs suffering from malignant tumors, especially in dogs with mammary carcinoma and smaller tumors and that increased serum IGF-1 concentrations could be an indication of large tumors and a poor prognosis. PMID:29755191
Leptin and insulin like growth factor 1 may support spermatogenesis in adult dogs and mediate Leydig cell function PMID:28101891
This study evaluated the role of IGF1 and phosphoinositol 3 kinase signaling in the pathogenesis of adrenocortical tumors in dogs and to identify pathway components that may hold promise as future therapeutic targets or as prognostic markers. PMID:25619516
These data strongly indicated a strong relathionship between fetal fluids IGF-I and nonesterified fatty acid concentrations and breed size exists. PMID:24674237
This study found that serum protein profiles and IGF-I concentrations were altered in both diabetic and insulin-treated animals. PMID:22122898
There was significantly higher expression of genes encoding for growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in metastases compared to their primary tumours. PMID:21507690
This study focuses on the co-expression of interleukin-4 (IL-4) and insulin-like-growth factor-1 (IGF-1), which specifically target inflammation and cartilage repair, respectively. PMID:20188584
variability in height between dogs were associated with dramatic differences in insulin-like growth factor 1(IGF1) and IGF binding protein 3 levels in plasma and follicular fluid and differences were associated with functional aspects of ovarian follicles PMID:20406781
inhibiting GSK3 increases brain insulin-like growth factor I levels PMID:20351102
a single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs PMID:17412960
Genetics are associated with body size in dogs. PMID:17502080
Study provides evidence that progesteron might increase autocrine Growth Hormone production which might directly stimulate local or systemic IGF-I secretion in canine mammary tumours. PMID:18367392
IGF-1/IGF-1R and cyclins are involved in the hypertrophic response observed in cardiomyopathies. PMID:19818143