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Recombinant Dog Inducible T-cell costimulator (ICOS), partial

Recombinant Dog Inducible T-cell costimulator (ICOS), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ICOS

Purity

>85% (SDS-PAGE)

Target Names

ICOS

Uniprot NO.

Q7YR73

Alternative Names

ICOS; AILIMInducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD antigen CD278

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Gene References into Functions

ICOS plays a role in graft rejection and graft vs host disease in an outbred animal model, and ICOS blockade may be an approach to prevention and treatment of chronic GVHD. PMID:23694952

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Database Links

UNIGENE: Cfa.167

KEGG: cfa:403456

STRING: 9615.ENSCAFP00000018974

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