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Recombinant Dog Granulocyte-macrophage colony-stimulating factor (CSF2)

Recombinant Dog Granulocyte-macrophage colony-stimulating factor (CSF2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CSF2

Uniprot NO.

P48749

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

18-144

Target Protein Sequence

APT RSPTLVTRPS QHVDAIQEAL SLLNNSNDVT AVMNKAVKVV SEVFDPEGPT CLETRLQLYK EGLQGSLTSL KNPLTMMANH YKQHCPPTPE SPCATQNINF KSFKENLKDF LFNIPFDCWK PVKK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Gene References into Functions

Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983 PMID:29304171
The results suggest that GM-CSF production mediated by the cysteine protease is regulated not only by NFAT but also by unknown signalling pathways in canine keratinocytes. PMID:23530471
This study suggests that interferon-gamma may suppress granulocyte-macrophage colony stimulating factor production from canine keratinocytes, although further studies are required to confirm this. PMID:20860556

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Subcellular Location

Secreted.

Protein Families

GM-CSF family

Database Links

UNIGENE: Cfa.3784

KEGG: cfa:403923

STRING: 9615.ENSCAFP00000001176

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