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Recombinant Dog Galactocerebrosidase (GALC), partial

Recombinant Dog Galactocerebrosidase (GALC), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

GALC

Uniprot NO.

P54804

Alternative Names

GALC; Galactocerebrosidase; GALCERase; EC 3.2.1.46; Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

27-669

Target Protein Sequence

YVLD DSDGLGREFD GVGAVSGGGA TSRLLVNYPE PYRSQILDYL FKPNFGASLH ILKVEIGGDG QTTDGTEPSH MHYALDENFF RGYEWWLMKE AKKRNPNIIL MGLPWSFPGW IGKGFNWPYV NLQLTAYYIM TWIVGAKHYH DLDIDYIGIW NERSFDINYI KVLRRMLNYQ GLDRVKIIAS DNLWEPISAS MLLDSELLKV IDVIGAHYPG THTVKDAKLT KKKLWSSEDF STLNSDVGAG CLGRILNQNY VNGYMTATIA WNLVASYYEQ LPYGRCGLMT AQEPWSGHYV VESPIWVSAH TTQFTQPGWY YLKTVGHLEK GGSYVALTDG LGNLTIIVET MSHKQSACIR PFLPYFNVSR QFATFVLKGS FSEIPELQVW YTKLGKPSER YLFKQLDSLW LLDSSSTFTL ELQEDEIFTL TTLTVGSKGS YPLPPKSEPF PQIYEDDFDV DYPFFSEAPN FADQTGVFEY FTNIEDPGEH RFTLRQVLNQ RPITWAADAY NTISIIGDYK WSNLTVRCDV YIETPEKGGV FIAGRVNKGG ILIRSARGIF FWIFANGTYR VTGDLAGWVI YALGRVDVTA KKWYTLTLII KGRLSSGMLN GKTVWKNIPV SFPKNGWAAI GTHSFEFAQF DNFHVEATR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.

Gene References into Functions

This study demonistrated that CNS and PNS disease progression can be quantified over time in the canine model of GLD with tools identical to those used to assess human patients. PMID:27638585

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Subcellular Location

Lysosome.

Protein Families

Glycosyl hydrolase 59 family

Database Links

UNIGENE: Cfa.3777

KEGG: cfa:403916

STRING: 9615.ENSCAFP00000031633

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