Recombinant Dog G1/S-specific cyclin-D1 (CCND1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

CCND1

Purity

>85% (SDS-PAGE)

Target Names

CCND1

Uniprot NO.

Q64HP0

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

1-295

Target Protein Sequence

MAHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EILPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLNRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPDELLQM ELLLVNKLKW NLAAMTPHDF IEHFLSKMPV AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLHLGSS NSFLSYHRLT RFLSKVIKCD ADCLRACQEQ IEALLESSLR QAQQQSLDPK AAEEEEEEEE ADLACTPTDV RDVNI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Gene References into Functions

The prognostic value of surgical margins, Ki-67 and cyclin D1 expression in the determination of prognosis in canine cutaneous mast cell tumor are reported. PMID:18057825
ZO-2 inhibits cell proliferation at G0/G1 and decreases CD1 protein level. PMID:19056685

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Subcellular Location

Nucleus. Cytoplasm. Nucleus membrane.

Protein Families

Cyclin family, Cyclin D subfamily

Database Links

UNIGENE: Cfa.16248

KEGG: cfa:449028

STRING: 9615.ENSCAFP00000015750

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