Recombinant Dog Cytochrome P450 2E1 (CYP2E1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

CYP2E1

Purity

>85% (SDS-PAGE)

Target Names

CYP2E1

Uniprot NO.

Q9MZY0

Alternative Names

CYP2E1Cytochrome P450 2E1; EC 1.14.14.1; 4-nitrophenol 2-hydroxylase; EC 1.14.13.n7; CYPIIE1

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

2-494

Target Protein Sequence

AALGITVAL LVWMATLMLI SIWKQIYSRW KLPPGPFPLP IIGNILQVDI KNVPKSLAKL AEQYGPVFTL YLGSQRTVVL HGYKAVKEVL LDHKNDLSGR GEVFAFQSHK DRGITFNNGP GWKDTRRLSL STLRDYGMGK RGNEERIQRE IPFLLEALRG TRGQPFDPTF LLGFAPFNVI ADILFHKHFD YSDQTGLRIQ KLFNENFHLL STGWLQLYNI FPSYLHYLPG SHRKVLRNVA ELKDYSLERV KEHQESLDPT CSRDFTDCLL QELQKERYGT EPWYTLDNIA VTVADLFFAG TETTSTTLRY GLLILMKYPE VEEKLHEEID RVIGPSRVPA IKDRLEMPYM DAVVHEIQRF IDLLPSNLPH VANQDTMFRG YVIPKGTVVI PTLDSVLFDK QEFPDPEKFK PEHFLNENGK FKYSDYFKAF SAGKRVCVGE GLARMELFLF LSAILQHFNL KSLVDPKDID LSPCTIGFAK IPPHYKLCVV PRSG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.

Gene References into Functions

significant role for CYP2E1 in the oxidative stress associated with chronic alcoholism PMID:21833537

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Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein.

Protein Families

Cytochrome P450 family

Database Links

UNIGENE: Cfa.28355

KEGG: cfa:415128

STRING: 9615.ENSCAFP00000034940

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