Recombinant Dog Caveolin-1 (CAV1), partial

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CAV1

Uniprot NO.

P33724

Research Area

Others

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

E.coli

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

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Target Background

Function(From Uniprot)

May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.

Gene References into Functions

results demonstrate that knockdown of EPLIN or Cav-1 substantially suppresses apical extrusion of transformed cells, implying that the expression of these molecules is required for the elimination of newly emerging transformed cells from the epithelium. PMID:25609711
Early intervertebral disc degeneration involves down-regulation of Caveolin-1 expression PMID:23360510
To better understand the role of caveolin-1 in bone homeostasis and response to beta-TCP scaffold, beta-TCP was implanted into mandible defects, and gene expression profiles were examined focused on the molecular components involved in caveolin-1 regulation. PMID:23401359
Malignant mammary cells showed a loss of Cav-1 expression. Our findings indicate that Cav-1 is a potential prognostic marker for canine mammary tumors. PMID:22370882
Alcohol promotes the myocardial oxidative stress and fibrosis through an elevated expression of PYK2 and a lowered expression of caveolin-1. PMID:21914371
Diminished function of human BCRP transfected into MDCK cells after canine Cav1 knockdown is likely mediated by alterations in protein-protein interactions and suggests a positive regulation of BCRP function by CAV1. PMID:20936466
these is a strong correlation between Cav-1-positive breast carcinomas and shorter overall survival in dogs. PMID:20153868
RNAi-mediated Cav-1 knock-down results in a decrease in virus titre in infected Madin-Darby canine kidney cells. PMID:20504340
These findings link increased expression of Cav-1 to neoplastic transformation and suggest that Cav-1 expression is associated with more malignant canine mammary tumours and their vascular invasion and regional lymph node metastasis. PMID:20153867
caveolin-1 does not play a major role in lipid raft-mediated biosynthetic membrane trafficking PMID:16260622
EGF-based signaling cascades phosphorylate Cav1 and have roles in caveolae assembly PMID:16332692
These data suggest that, upon stimulation, Galpha(q)(GTP) switches from having strong interactions with Gbetagamma to Cav1, thereby releasing Gbetagamma. PMID:18397999

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Subcellular Location

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network.

Protein Families

Caveolin family

Database Links

UNIGENE: Cfa.3850

KEGG: cfa:403980

STRING: 9615.ENSCAFP00000005060

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