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Recombinant Dog Cardiac phospholamban (PLN), partial

Recombinant Dog Cardiac phospholamban (PLN), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

PLN

Uniprot NO.

P61012

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Gene References into Functions

PLB mRNA was reduced 16-fold, and PLB protein was reduced 5-fold. PMID:21542669
PLB decreases Ca(2+) binding to SERCA2a by stabilizing a unique E2.ATP state that is unable to bind thapsigargin or vanadate. PMID:20622261
Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban PMID:19948724
phospholamban leucine 31 has roles in structural and functional interactions with SERCA2a PMID:15644311
Phospholamban (PLB) oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase (SERCA) binding were quantified by fluorescence resonance energy transfer (FRET) in an intact cellular environment. PMID:18287099
Activation of cardiac muscle sarcoplasmic reticulum calcium-transporting ATPase (SERCA2a) dephosphorylation by nitroxyl (HNO) is PLN-dependent; PLN thiols are targets for HNO. PMID:19053265

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein.

Protein Families

Phospholamban family

Tissue Specificity

Heart.

Database Links

UNIGENE: Cfa.3816

KEGG: cfa:414755

STRING: 9615.ENSCAFP00000036921

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