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Recombinant Dog Brain-derived neurotrophic factor (BDNF)

Recombinant Dog Brain-derived neurotrophic factor (BDNF)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

BDNF

Purity

>85% (SDS-PAGE)

Target Names

BDNF

Uniprot NO.

Q7YRB4

Alternative Names

BDNF; Brain-derived neurotrophic factor; BDNF) [Cleaved into: BDNF precursor form; ProBDNF)]

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

129-247

Target Protein Sequence

HS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT LTIKRGR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Gene References into Functions

BDNF, TAC1 and CCK genes may be associated with learning and memory in dogs. These genes are found to be expressed in the dog hippocampus. The study provides also analysis of promoters of these genes and phylogenetic analysis of protein sequences. PMID:25192892
Nonpharmacological changes in lifestyle in advanced age can upregulate BDNF to levels approaching those in the young brain. PMID:20447733

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Subcellular Location

Secreted.; [BDNF precursor form]: Secreted.

Protein Families

NGF-beta family

Database Links

UNIGENE: Cfa.170

KEGG: cfa:403461

STRING: 9615.ENSCAFP00000014984

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