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Recombinant Didelphis marsupialis virginiana Beta-adrenergic receptor kinase 1 (ADRBK1), partial

Recombinant Didelphis marsupialis virginiana Beta-adrenergic receptor kinase 1 (ADRBK1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

GRK2

Uniprot NO.

O97627

Alternative Names

GRK2; ADRBK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2

Species

Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)

Source

Yeast

Expression Region

1-689

Target Protein Sequence

MADLEAVLAD VSYLMAMEKS KATPAARASK KILLPEPSIR SVMQKYLEDR GEVTFEKIFS QKLGYLLFRE FCLNHMEEAK PLVEFYDEIK KYEKLDSEEE RTVKSREIFD LYIMKELLSC SHLFSKSATE HVQSRLLKKQ VPTDLFQPYI EEICQRFRDD VFQKFIESEK FTRFCQWKNV ELNIHLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER IMLSLVSTGD CPFIVCMSYA FHTPDKLSFI LDLMNGGDLH YHLSQHGVFS ESDMRFYAAE IILGLEHMHS RFVVYRDLKP ANILLDEFGH VRISDLGLAC DFSKKKPHAS VGTHGYMAPE VLQKGVAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTMA VELPDSFSPE LRSLLEGLLQ RDVNRSLGCL GRGAQEVKED PFFKAVDWQM VLLQKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD SDQELYRNFP LTISERWQQE VAETVFDTVN SETDRLEARK KAKNKQLGHE DDYALGKDCI MHGYMSKMGN PFLTQWQRRY FYLFPNRLEW RAEGEAPQSL LTMEEIQSVE ETQIKDRKCI LLKIRGGKQF ILQCDSDPEL VQWKKELRDV YREAQQLLQR VPKMKNKPRS PVVELSKMPL TQRGSANGL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Does not act on HTR1B/5-hydroxytryptamine 1B receptor. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Inhibits relaxation of airway smooth muscle in response to blue light.

Subcellular Location

Cytoplasm. Cell membrane.

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily

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