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Recombinant Danio rerio TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (tab2), partial

Recombinant Danio rerio TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (tab2), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

tab2

Purity

>85% (SDS-PAGE)

Target Names

tab2

Uniprot NO.

Q5RFW2

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-711

Target Protein Sequence

MAQGNQQIDN QVLHHLRQKF PEVPEDVVCE CVLQNKSDLA ACCEYLTKVS PRFLYSEGSQ SLTDLRNHMT QLNLGVSQNT HGAVQRDAVG MNGSRTLAPS VSDGPLNVPS ALSEFYQPET PSVPTHTPAS LSMESTRKPQ PPQHLGLYQV GGKGHAPPQA PRFNPITVTL APNTGRNTPT SLHIHGGPQS GLNSPNSIYI RPYVTQPGST RQVQCRAQYS PTSQPAQQIY QITHPAAPQS SWSQHQTSHV YMPISSPTNT QAPSIPSAVA SQAVSSSPLP SSGSSFSQYN IQNISTGPRK NQIEIKLESP QRGSGSSSLL RSSSAPRSAC SSTSSSCPSS CTSLASSSGS STPISIGGAG LSRSQPTVYI SPSPPTAATA PSEDCALVPN TPRSQPKIYF SANTSADDGG GRNPPTVYIS ANPALQGPAG LRALGSQMSM GPAYIHHHPP KSRPSVGAGG TATSPRVVVT QPNTKYTFKI TVSPNKPPSV SPGVVSPTFE PNNMLSLPAD HHYAEPEISQ PDPMRDKAVE PRRLSMGADD AAYTQALLVH QRARMERLWH ELELKKRKLE KLKEEVNEME SDLTRRRLQR SNAFCQIPSI EEMQQLRCKN RLLQIDIDCL TKEIDLLQTR GPDFNPIAIH NFYDNLGFLG PVPPKPLKGP TKAEVSRTDA GVRVLSEPEE DDGVQWSCTA CTFLNHPALN RCEECEFPRN F
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Involved in heart development.

Gene References into Functions

a critical, dosage-sensitive role during development was demonstrated by the cardiac defects observed upon titrated knockdown of tab2 expression in zebrafish embryos PMID:20493459

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Subcellular Location

Membrane; Peripheral membrane protein. Cytoplasm, cytosol.

Database Links

UNIGENE: Dr.134676

KEGG: dre:494163

STRING: 7955.ENSDARP00000116375

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