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Recombinant Danio rerio Serine/threonine-protein kinase PLK4 (plk4), partial

Recombinant Danio rerio Serine/threonine-protein kinase PLK4 (plk4), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

plk4

Purity

>85% (SDS-PAGE)

Target Names

plk4

Uniprot NO.

Q7ZVS3

Alternative Names

plk4; sak; Serine/threonine-protein kinase PLK4; EC 2.7.11.21; Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase Sak

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-940

Target Protein Sequence

MSVSIGDKIE DFKVLTLLGK GSFACVYRAK SVNTGLEVAI KMIDKKAMHK AGMVQRVINE VEIQCRLKHP SVLELYNYFE DSNYVYLVLE MCHNGEMSRY LKERKNPFTE EEARHFMHQI VKGMLYLHTH GIMHRDLTLT NLLLTTSMNI KIADFGLATQ LKLPSEKHFT MCGTPNYISP EVATRSAHGL ESDVWSLGCM FYAFLTGRPP FDTDTVKRTL NKVVLGEYQM PMHISAEAQD LIQQLLQKNP ALRPSLSAVL DHPFMTQSGP TASKDSGSSN GGSIDSGIAT ISTASNATNN SSSSRLQRRT RQMIGQPLPS RMAPIPSHSH HSTSSSFKSG QDWQPNSQDD LSRMGVGRIP VGADSGRPHS RYLRRAHSSD RSAVGYSHNP QEAELERCHS EEMLSGAGRL FPQTSGYRNA PHGYSKHDRL PSPPVKQPAN PASSFSTSTH STRQQMPDSQ TQPWFSNDGV FKRPADMSGH SSSGSFHSER GPIGTQTSCS DKPSGLHSQQ QPILFQHNNP GPCREDAFVS GHMSEPQAYS DAQFPCPPLS KGKANTEKKD KVCLKKSFPP LCAARLKPIR QKTKNAVVSI LGNGEVCMEL LKGQGAQERV KEVLRISCDG SMVTVYQPNE GKGFPVLDHP PSPPEDILIC SFDDLPEKYW KKYQYATKFV QLVKSKTPKV TLYTKFAKCM LMENSPNPDL EVCFYDGAKT HKTSEQVRVV EKSGKSYTVK GDVGLSGLNP ECRLYIELSE EGHRMCLSLE AAITAEEQRS AKNTPFFPIT IGRRPVNPVP PAPAPSSSSS CRPAAAAEVA HVCLSPPQHP QITPSMISYA GSDLTTASVA KGSSPVHKDE RTVNSGKVLK SIFVPNIGWV SQLTTGEVWV QFNDGSQLMV QVGVSCIIFT SPEGHITRYK ENEKLPELVK EKLHCLSSIL GLLANPAARC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles.

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily

Database Links

UNIGENE: Dr.80660

STRING: 7955.ENSDARP00000043865

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