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Recombinant Danio rerio Protein kinase C iota type (prkci), partial

Recombinant Danio rerio Protein kinase C iota type (prkci), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

prkci

Purity

>85% (SDS-PAGE)

Target Names

prkci

Uniprot NO.

Q90XF2

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-588

Target Protein Sequence

MPTLRDSTMS HPGENPHQVR VKAYYRGDIM ITHFEPSISY EGLCNEVRDM CSMDNDQLFT MKWIDEEGDP CTVSSQLELE EALRLYELNK DSELIIHVFP CVPEKPGMPC PGEDKSIYRR GARRWRKLYY ATGHAFQAKR FNRRAHCAIC TDRIWGLGRQ GYKCINCKLL VHKKCHKLVT VECGRQVIQD PMIGRIDPGS THPEHPDQVL GKKNSTESIN HEGEEHEAVG SRESGKAVSS LGLIDFDLLR VIGRGSYAKV LLVRLKKTER IYAMKVVKKE LVNDDEDIDW VQTEKHVFEQ ASNHPFLVGL HSCFQTESRL FFVIEYVNGG DLMFHMQRQR KLPEEHARFY SAEISLALNY LHERGIIYRD LKLDNVLLDS EGHIKLTDYG MCKEGLRPGD TTSTFCGTPN YIAPEILRGE DYGFSVDWWA LGVLMFEMMA GRSPFDIVGS SDNPDQNTED YLFQVILEKQ IRIPRSLSVK AASVLKGFLN KESKERLGCH PQTGFADIMA HPFFRNVDWD LMEQKQVVPP FKPNISGEFG LDNFDAQFTN EPIQLTPDDD DAVKKIDQSE FEGFEYINPL LMSAEECV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division.

Gene References into Functions

aPKC regulates apical localization of Lgl1 and Lgl2 to restrict elongation of microridges in developing zebrafish epidermis. PMID:27249668
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta. PMID:25446529
a loss of zBves affects the proteins involved in the pathway of the PAR junctional complex, especially aPKC, and both aPKC and Bves are indispensable to claudin expression. PMID:23019331
These results suggest that the aPKC cell autonomously controls the Golgi localization and thereby regulates the specification of the primary dendrite of Purkinje cells. PMID:21159968
Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis. PMID:16319113
PrkCi function and planar divisions are necessary for asymmetric, self-renewing division of spinal cord precursors. PMID:19449304