Recombinant Danio rerio Nibrin (nbn), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

nbn

Purity

>85% (SDS-PAGE)

Target Names

nbn

Uniprot NO.

Q5I2W8

Alternative Names

nbn; nbs1; zgc:194152; Nibrin; Nijmegen breakage syndrome protein 1 homolog

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-818

Target Protein Sequence

MWKLQPTESG GESVILLAGQ EYVVGRKNCE ILLTNDQSIS RVHAVLTVTE QAVTLKDSSK YGTFVNGEKL ESGSTKTLQT GYKITFGVFQ SKFSLEKECI VVCSSCVDNE GKVTLSQDIR SVGGRLVSSW TSDCTHLVMP TVKVTIKTIC ALLCCRPIVK PAFFSALSKA VQQKLPLPKA ERFRPQIDEP SLARDDVDLS ARPERKSLFK GKTFLFLSSK QMKRLSVAVS CGGGVSQLLD EGALPVSLLE SSSTCVLDMI SGNSQPVISP ASKKWLDSVG QILHRKGLRF ITESEVGLAA IHVSNQTYCN PCSSLQSESV KTNPVFASAT LSQSTAVDET ALAAPSQNIT AYVVNTEISQ DQSRMVTSGI SAVGETPEKT NPTQKASTTN KPLSLGQEPS STRIVQETVM SSESFSVVES EQKMKKGSVV SARGRVEGPV KQKAPSSGNT TLKHSPQKQT ALTSFFQPSS KKRPRESSAS SVQPEPKFFK KDIKDNEDDI QQSFSVNRSH KTSSEETSLG QACGTGQNSS SKKRKEPEQD TLLGAEEPTA ADDLEMSLEE LEFLMSDEMD EPPQTAANKK QRLESGLTSK INSEQLSNQQ EVTESKGRKG EKNQQSSSSN IQSMQLDRAG PAVTNQDTQT QSKRSPPDLE AHSSANKGPS KNKTPELEEV KKEEVSFVVN SRPQNGISQT SEAVLKQEMQ ASTSNSGPKN DPDLPRKLLQ VQFMSLTVNN SSRSRPGPLQ THNPNDKNVK RFRKKNVPGF DGLPKIIGGS DLVAHNRSKH SELEEWLRQA AEEEKLNERE ETLGDDLFRY NPRPAKKR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity.

Subcellular Location

Nucleus. Chromosome, telomere.

Database Links

UNIGENE: Dr.83220

KEGG: dre:544655

STRING: 7955.ENSDARP00000121705

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