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Recombinant Danio rerio Neurogenic differentiation factor 1 (neurod1)

Recombinant Danio rerio Neurogenic differentiation factor 1 (neurod1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

neurod1

Uniprot NO.

O42202

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-350

Target Protein Sequence

MTKSYSEESM MLESQSSSNW TDKCHSSSQD ERDVDKTSEP MLNDMEDDDD AGLNRLEDED DEEEEEEEED GDDTKPKRRG PKKKKMTKAR MQRFKMRRMK ANARERNRMH GLNDALESLR KVVPCYSKTQ KLSKIETLRL AKNYIWALSE ILRSGKSPDL MSFVQALCKG LSQPTTNLVA GCLQLNPRTF LPEQSQEMPP HMQTASASFS ALPYSYQTPG LPSPPYGTMD SSHIFHVKPH AYGSALEPFF DTTLTDCTSP SFDGPLSPPL SVNGNFSFKH EPSSEFEKNY AFTMHYQAAG LAGAQGHAAS LYAGSTQRCD IPMENIMSYD GHSHHERVMN AQLNAIFHDS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.

Gene References into Functions

during embryonic development, NeuroD governs photoreceptor genesis via non-cell-autonomous mechanisms and that, during photoreceptor development and regeneration, Notch signaling is a mechanistic link between NeuroD and cell cycle exit. PMID:26580854
differential levels of Neurod are required to generate endocrine pancreas subtypes from precursors during both embryonic and larval stages PMID:25797153
Transcription factor neuroD, involved in retinogenesis, is co-opted by the circadian clock following photoreceptor differentiation. PMID:24924194
Nkx2.2 coordinately activates NeuroD1 with Ngn3 in the endocrine progenitor cell and plays a role in the maintenance of NeuroD1 expression to regulate beta cell function in the mature islet. PMID:19759004
The control of endocrine cell fate is instead fulfilled by two basic helix-loop-helix factors, Ascl1b and Neurod1 and NEUROG3 is not the unique pancreatic endocrine cell fate determinant in vertebrates. PMID:23835295
the quantity, rather than quality (i.e., the ON/OFF states), of neurod expression directly or indirectly determines the two subtypes of posterior lateral line neurons PMID:23303935
BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain. PMID:12204253
in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1 PMID:16678150
Coexpressed with cone-rod-homeobox transcription factor (Crx) in putative cone progenitors and nascent cone photoreceptors. In zebrafish retina, similar genetic cascades may regulate photoreceptor genesis and maturation. PMID:17206615
NeuroD plays a fundamental role in photoreceptor genesis by regulating mechanisms that promote rod and cone progenitors to withdraw from the cell cycle. PMID:19121642

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Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

In the embryo, expressed broadly in a subset of primary neurons in the brain and spinal cord. At 28 hours post-fertilization (hpf), regions of expression include telencephalon, olfactory placode, epiphysis, cranial ganglia, acoustic ganglia, Rohon-Beard m

Database Links

UNIGENE: Dr.75801

KEGG: dre:30169

STRING: 7955.ENSDARP00000026490

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