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Recombinant Danio rerio Mothers against decapentaplegic homolog 2 (smad2)

Recombinant Danio rerio Mothers against decapentaplegic homolog 2 (smad2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

smad2

Purity

>85% (SDS-PAGE)

Target Names

smad2

Uniprot NO.

Q9I9P9

Alternative Names

smad2; madh2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; SMAD family member 2; SMAD 2; Smad2

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-468

Target Protein Sequence

MSSILPFTPP VVKRLLGWKK SASGSSGAGG GGEQNGQEEK WCEKAVKSLV KKLKKTGQLD ELEKAITTQN RNTKCVTIPS NCSEIWGLST PNTIEQWDTS GLYSYPDQTR SLDGRLQVSH RKGLPHVIYC RLWRWPDLHS HHELRAIETC EYAFNLKKDE VCVNPYHYQR VETPVLPPVL VPRHTEILTE LPPLDDYTNS IPENTNFPTG IEPPNNYIPE TPPPGYISED GEASDQQMNQ SMDTGSPAEL SPSTLSPVNH GMDLQPVTYS EPAFWCSIAY YELNQRVGET FHASQPSLTV DGFTDPSNSE RFCLGLLSNV NRNATVEMTR RHIGRGVRLY YIGGEVFAEC LSDSAIFVQS PNCNQRYGWH PATVCKIPPG CNLKIFNNQE FAALLAQSVN QGFEAVYQLT RMCTIRMSFV KGWGAEYRRQ TVTSTPCWIE LHLNGPLQWL DKVLTQMGSP SVRCSSMS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis.

Gene References into Functions

The non-Smad JNK signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad pathway, and this nuclear movement is associated with Smad signal transduction toward the nucleus. PMID:28947537
The results of this study found that Bptf and TGF-beta/Smad2 mediate nucleosome remodeling to regulate wnt8a expression and hence neural posteriorization. PMID:26041917
Smad2 and Eomesodermin a (Eomesa) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa forms a general component of the Smad2 signalling complex in zebrafish. PMID:25277163
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation. PMID:17276343
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription PMID:21669877
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning. PMID:18025082
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis PMID:19580801