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Recombinant Danio rerio Mitogen-activated protein kinase 12 (mapk12)

Recombinant Danio rerio Mitogen-activated protein kinase 12 (mapk12)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

mapk12

Uniprot NO.

O42376

Alternative Names

mapk12; sapk3; Mitogen-activated protein kinase 12; MAP kinase 12; MAPK 12; EC 2.7.11.24; Stress-activated protein kinase 3

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-363

Target Protein Sequence

MTARSRPGYF RQEINKTIWE VPDRYKDLKQ VGTGAYGTVC YALDRRTGAK VAIKKLHRPF QSDLFAKRAY RELRLLKHMK HDNVIGLVDV FTADLSLDRF HDFYLVMPFM GTDLGKLMKM ERLSEERVQY LVYQMLKGLK YIHAAGIIHR DLKPGNLAIN EECELKILDF GLARQTDSEM TGYVVTRWYR APEVILSWMH YTQTVDIWSV GCIMAEMLLG KPLFKGHDHL DQLMEIMKVT GTPSKEFTAK LQSEDARNYV TKLPRFRKKD LRILLPNVNP QAIKVLDGML LLDPESRITA AEALAFPFFS EFREPEEETE APPYDHSLDE ADQSLEQWKR LTFTEILTFQ PAPAVAESKE TAL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets.

Subcellular Location

Cytoplasm.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily

Database Links

UNIGENE: Dr.104488

STRING: 7955.ENSDARP00000011298

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