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Recombinant Danio rerio Kinesin-like protein kif7 (kif7), partial

Recombinant Danio rerio Kinesin-like protein kif7 (kif7), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

kif7

Purity

>85% (SDS-PAGE)

Target Names

kif7

Uniprot NO.

Q58G59

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-1363

Target Protein Sequence

MSPKGVGHSK VEESAVQVAV RVRPLLPKEI LHSHESCITS DPEERRVTLG NDRHFHCDFV FEDGSTQEEV YTNCVQPLIE AFFHGFNATV SAYGQTGSGK TYTIGEASIS AFRDDEQGII PRAVAEIFKL LDENDLIDFS VRVSYMEVYK EVFRDLLEVE TASKDIHIRE DERGNVVLCG VKECEVEGLD EVLSLLESGK TARHTGATQM NPHSSRSHTI FTVLMEQRRG GSRAANGSVQ ILSSKFHFVD LAGSERILKT GNTGERLKES IQINSGLLVL GNVIGALGDP KRKGTHIPYR DSKITRILKD SLGGNAKTLM IACISPSSSD FDESLNTLNY AKRARNIQNR ATVNCRGEPD RIEGLELQIK ALRRALENRQ RSETRIIARS DPEKRLRPFE VDVRKLQAES AHYRTCTDSA YRLLTELQGE GTLNAGQILR VKEWLCGVEE ERSGLTSASG LDSGIESSST EDSTALKRRQ AVLNNQDLVK EDWRGEREDY TSQLQAQIQQ LEQENTDFLV ALEDAMEQYK QQSDKLQEQQ DLIAELHSLL AQPGGAGFLH LKQRPHTAPI NSLLQTPDRL TPPCDSDVGR SLARQLDVGA SVDSSSYSEQ TQWDGTHGNT HCESSRKLNR DEDGHMQTTR DKRKSINVTW TKKDIAIPQG PFGGTRTALP QTLGLCHPLG MQFNRRTSNS SIGESSVWES VRGFGGEFCS DRGLLQAQQK IRELSITIRM KEELIKELVK TGKDAQAMNR QYSRKISELE AEAEQARVEL TEAQKQLQEL EVQGGRDAVD RSKAQECRRK IAAAQSKVQV LKQKQRDTAQ LASLSAQSER RVQELERNVQ NMKQQQDLLQ RRLREESQQK RRLETEMQKG KHRVKELEIK NEQQQKILRI KTEEIAAFQR QRRSGSNGSV VSLEEQQKIE EQKRWLDEEM EKVLDQRRGL EDLEGELTKR EEILAKKEAL LWERSGLESK KLRSSQALSQ DLLTLSSRIE SLERELTERN GLLRSGSAQD SQQIRQEISN LRQEKELLLK QRVELDDKLR QGNLLSPEEE RTLFQLDEAI EALDAAIEYK NEAITQRQRQ LRASGSMLTQ WEMNLMAKLT YLSASETRAL LCKYFDKVVS LREEERRLQM ALAELELRVE EQQNLVGWLE AALERQQLEA DRRLTQQQKE HERNIQLLLQ QCREQMDEGL AGRLRQYEGL IHNLSKELNF CKIANQELNI KLREMCGPVN LTGEQCKGLN CDSLLLAGAQ SRVAEDVKPI IDAERVQKSR EEMREPVNAP LPATWRRSSL PTEDQYTMEE LRQRAACELP NNRIVQPGMN STHWSGSTSL PVTRPRREPR RSSLNTAPLY SSSAIIDVRR NPV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics.

Gene References into Functions

both osm-3/kif17 and cos2/kif7 have comparable outer segment developmental delays, although through independent mechanisms. PMID:28341548
We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in Drosophila PMID:24339784
zebrafish Costal2 acts as an intracellular repressor of signal transduction PMID:15647323

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Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, cilium.

Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIF27 subfamily

Database Links

UNIGENE: Dr.86796

KEGG: dre:544651

STRING: 7955.ENSDARP00000041576

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