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Recombinant Danio rerio Insulin (ins), partial

Code
MSDS
MSDS Datasheet
Size Pls inquire
Source
Conjugate
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ins
Uniprot NO.
Alternative Names
ins; Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Source
Yeast
Expression Region
22-51
Target Protein Sequence
NPGTPQHLC GSHLVDALYL VCGPTGFFYN P
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Partial
Tag Info
N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Buffer
Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Storage Condition
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Gene References into Functions
  1. Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages. PMID:16849636
  2. These findings suggest that GHRL regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor in the central nervous system and partly involved in carbohydrate-glycogen metabolism. PMID:20138234
  3. Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain. PMID:17196948

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Subcellular Location
Secreted.
Protein Families
Insulin family
Database Links

UNIGENE: Dr.75811

KEGG: dre:30262

STRING: 7955.ENSDARP00000051221

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Related pathways
HIF-1 signaling pathwayMAPK signaling pathwaymTOR signaling pathwayPI3K-Akt signaling pathwayRegulation of actin cytoskeletonAutophagyRas signaling pathwayAMPK signalingcGMP-PKG signaling pathwayFoxO signaling pathwayInsulin signaling pathwayPhospholipase D signaling pathwayRap1 signaling pathway
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