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Recombinant Danio rerio Inhibitor of nuclear factor kappa-B kinase subunit alpha (chuk), partial

Recombinant Danio rerio Inhibitor of nuclear factor kappa-B kinase subunit alpha (chuk), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

chuk

Purity

>85% (SDS-PAGE)

Target Names

chuk

Uniprot NO.

Q4G3H4

Alternative Names

chuk; ikk1; zgc:56539; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; EC 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-758

Target Protein Sequence

MEKPPFRQNQ VCGSWVMKER LGTGGFGHVY LYQNQETSEK IAVKLCRLEL NSKNKDRWSR GIQIMKKLKH LNVVTAKDVP EEMMHIALND LPLLAMEYCS KGDLRKLLSK PENCCGLKES EVLSLLNDVG SGIQYLHENK IIHRDLKPEN IVLQEINGKL VHKIIDLGYA KDLDQGSLCT SFVGTLQYLA PELFEGKSYT VTVDFWSFGT MIFECCCGFR PFLHNLQPVQ WTSKVRNKGP KDIMAVEDMN GEVRFSTHLP YPNNLSRTLL EPLEGLLQLM LKWDPVQRGL GLNTDSKQPQ CFVLLDQILS MKVVHILNMT TTQVHSFLLS PDEGLHSLQQ RIENETKIEL LNQDLLQETG VMSDPRKPAA QCVLDGVRGW DSYIVYLFDK SLTKYMGPLT ARTLPESVNF IVRETKTQLP LSTLKKVWGE AVSYICGLRE DYSRLFQGQR AAMLSLLRFN TNLTRYKNMM FSFSQQLKAK LDFFKTSIQY DLEKYSDQMQ YGISSEKMLK AWHENEERAA AFAQVAEIGH LDEEIMALHS EIVELQRSPY ARRQGDVMEQ LQEKAIELYK QLKAKCKMPD PQHGYSDSSE MVKVIVQTVQ NQDRVLRDLY AHLSKILLSK QKIIDLFPKI ERTLECIKEA DTTVMQMQIK RQREFWHLLK IACAQNTTRS SVSQSGEMPS SLSTWNQTQA QCSSRLPMSL QVPHEGDSVN HLLEENQRYL TQLTSLLQET TEEKSESIMA QDWSWTKYES LVAKSPRL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Gene References into Functions

These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta and cell motility controlled by Rap-integrin signaling. PMID:24290981
poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis PMID:20692251
Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB. PMID:16051172

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily

Database Links

UNIGENE: Dr.14012

KEGG: dre:393287

STRING: 7955.ENSDARP00000013115

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