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Recombinant Danio rerio G1/S-specific cyclin-D1 (ccnd1)

Recombinant Danio rerio G1/S-specific cyclin-D1 (ccnd1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

ccnd1

Purity

>85% (SDS-PAGE)

Target Names

ccnd1

Uniprot NO.

Q90459

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-291

Target Protein Sequence

MEHQLFCCEV DTIRRAYQDS NLLNDRVLQT MLKAEENYLP SPNYFKCVQK EIVPKMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS VEPTKKTRLQ LLGATCMFLA SKMKETVPLT AEKLCIYTDN SVRPGELLQM ELLALNKLKW DLASVTPHDF IEHFLAKLPI HQSSKQILRK HAQTFVALCA TDVNFIASPP SMIAAGSVAA AVQGLYLKST DSCLSSQNLT NFLSQVIRSD PDCLRSCQEQ IESLLESSLR QAQQHISTET KRVEEDVDLS CTPTDVRDIN I
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.

Gene References into Functions

Methylparabens exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group. PMID:29360218
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of PMID:27756483
show that the knockdown of smc1a in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels PMID:26206533
Reduction of cyclin D1 expression compromises zebrafish eye and head development. PMID:16284195
Role in cell cycle control is mediated by meis1 regulating cyclin D1 and c-myc transcription in the embryonic eye. PMID:18216175