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Recombinant Danio rerio Early growth response protein 1 (egr1), partial

Recombinant Danio rerio Early growth response protein 1 (egr1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

egr1

Uniprot NO.

P26632

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-511

Target Protein Sequence

MAAAKTEMLL PALQISDPLS FPHSPTDNYP KLEEMIMLNS AGTPFLNATA PEGAVFGSGE PGEQFDHLAG DTLSEISMEK PLSDQTYSTQ RLPPISYTGR FTLEPATNCS NSLWAEPLFS LVSGLVGINP PPASIPSSTS QATHPSSSST SSIPSSSSSS TSSASLSCSV HQSEPNPIYS AAPTYSSASP DIFPESGPNF STTVGTSLQY SSSTYPSAKT CNPSFSVPMI PDYLFTQQQS EISLVPPDQK PIQTQAGQQP ALTPLHTIKA FATQTGSQDL KSVYQSQLIK PSRMRKYPNR PSKTPPHERP YACPVETCDR RFSRSDELTR HIRIHTGQKP FQCRICMRNF SRSDHLTTHI RTHTGEKPFA CEICGRKFAR SDERKRHTKI HMRQKDKKAE KGATAAVQSS VSNISISASS PVSSYPSPIT SYPSPVSSFP SPVNSCYSSP VHTSYPSPSI ATTYPSATST FQTQVATSFP TSVASNIYSS PVTTPLPDMQ SALSPRTADI C
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes. Plays a role in regulating the expression of circadian clock genes.

Gene References into Functions

egr1 colocalizes with tyrosine hydroxylase in the olfactory bulb throughout brain development. PMID:23022747
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish PMID:23209659
The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization PMID:12351200
Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos. PMID:17110908