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Recombinant Danio rerio Deleted in azoospermia-like (dazl)

Recombinant Danio rerio Deleted in azoospermia-like (dazl)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

dazl

Purity

>85% (SDS-PAGE)

Target Names

dazl

Uniprot NO.

Q9YGW7

Alternative Names

dazl; zdazl; Deleted in azoospermia-like; DAZ-like protein; zDazl

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-229

Target Protein Sequence

MVQGVQLPVC LICGLYSQDI QKHRQGFPSS LKLSNGYILP EGKMTPNTLF VGGIDMKVDE NEIREFFAKY GSVKEVKIIT YRGGICKGYG FVYFSEDVDI QTIVDQPISF KGKKLKLGPA IMKERSSRSV SSPMIGPSQW VNPTPYMYCS CCPPGLAPPS PVFSGGNQYM QPYSYSSPPG IMVPQVPMNY AQTTYAYQYP LPQWCGEQRT RLVNQNFVDC GVQTLLTLM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

RNA-binding protein involved in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts. Establishes oocyte polarity through interaction with Bucky ball (BUC). Interacts with Bucky ball (BUC) mRNA to mediate Balbiani body formation and oocyte polarity during early oogenesis.

Gene References into Functions

Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl, in the zebrafish embryo have been presented. PMID:26528729
that DAZL specifically binds the HuB 3'UTR and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein. PMID:21695151
DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish PMID:19838299
Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates. PMID:12296827

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Subcellular Location

Cytoplasm.

Protein Families

RRM DAZ family

Tissue Specificity

Testis and ovary specific. In ovary, it is localized in the cortex of oocytes. At the onset of embryogenesis, maternal product is located at the vegetal pole, before migrating toward blastomeres through cytoplasmic streams as early embryogenesis proceeded

Database Links

UNIGENE: Dr.81259

KEGG: dre:58039

STRING: 7955.ENSDARP00000052602

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