Recombinant Danio rerio Axin-1 (axin1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

axin1

Uniprot NO.

P57094

Alternative Names

axin1; axinAxin-1; Axis inhibition protein 1

Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Source

Yeast

Expression Region

1-835

Target Protein Sequence

MSMSVNEKGI CYLPDLGSSF TEDAPRPPVP GEEGDLVSSD GRQYNHSFYS SKSDSLKNEA SIATPRRPDL DLGYEPEGSA SPTPPYLKWA ESLHSLLDDQ DGIHLFRTFL KQEECADMLD FWFACSGFRK QEANDGNEKM LKLAKAIYKK YILDNNGIVS RQIKPATKSF IKDCVTKLHI DPAMFDQAQT EIQTMMEENT YPLFLKSDIY LEYTRTGGES PKLFSDQSSV SGNGKVLPGY LPTVIEDVEW RCDQEEEQIA ESDPTPSNRL TQKLPLETVP QRVANSKRYQ DNREYRHASW REPVNPYYVN SGYALAPATS ANDSEQQSMS SDADTLSLTD SSVDGVPPYR YRKPHRREIH ESAKVNGRVP LPHIPRTNRI PKDIHVEPEK FAAELISRLE GVLREREAQE KLEERLKRVR LEEEGDDADI STGPSLANHR VPPAVHVQHY GGRYSEMSYN GLQLRDAHEE NPESILDEHV QRVMKTPGCQ SPGTGRHSPK SRSPDGLPAG KIPGLMMPLS GGQGKHQARQ GPKGEAAHLH HHKHIHHTHY AAAGKPKEQA EAEAARMHGG FAWNTEQHHY GPKSRNYADG MSVGPNTMDP MGYSSKGSTL SKRPVRKGED GRNFEMREPL PADDMERNQK ILQWMMEGEK EAGRYKRGPY GSISGPKKAQ GHEPARPSSV ERLGAVHPWV TAQLRNNVQP SHPFIQDPTM PPNPAPNPLT QLEEARRRLE EERRKSGTLQ AKQRHKNMKK QPCENITVAY YFRGEPIPYR TSVKGRIVTL GQFKELLTKK GSYKYYFKKV SYEFDCGVVF EEVREDDAIL PIFEEKIIGK VEKVD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.

Gene References into Functions

beta-catenin1 cannot revert the ich phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS domain function. PMID:25335865
analysis of differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation PMID:22957046
Wnt/Axin/beta-catenin pathway has a role in ventral CNS development PMID:15539488
Overactivation of Wnt/Axin1/beta-catenin signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling. PMID:17678853
A dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis, is defined. PMID:17681137
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing PP1 from binding Axin PMID:19581931