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Recombinant Cynops pyrrhogaster Sonic hedgehog protein (SHH)

Recombinant Cynops pyrrhogaster Sonic hedgehog protein (SHH)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

SHH

Purity

>85% (SDS-PAGE)

Target Names

SHH

Uniprot NO.

Q90385

Alternative Names

SHH; Sonic hedgehog protein; SHH) [Cleaved into: Sonic hedgehog protein N-product; Sonic hedgehog protein C-product]

Species

Cynops pyrrhogaster (Japanese fire-bellied newt)

Source

Yeast

Expression Region

27-432

Target Protein Sequence

CGPG RGIGTRKRFK KLTPLAYKQF TPNVPEKTLG ASGRYEGKIT RNSERFKELT PNYNPDIIFK DEENTGADRL MTQRCKDKLN ALAISVMNQW PGVKLRVTEG WDEDGHHFEE SLHYEGRAVD ITTSDRDRSK YGMLARLAAE AGFDWVYFES KAHIHCSVKA ENSVAAKSGG CFPGSATVAL EQGVRIPVKD LRPGDRVLAA DGLGKLVYSD FLLFMDKEET VRKVFYVIET SRERVRLTAA HLLFVGQAHP GNDSGGDFRS VFGSAGFRSM FASSVRAGHR VLTVDREGRG LREATVERVY LEEATGAYAP VTAHGTVVID RVLASCYAVI EEHSWAHWAF APLRVGLGIL SFFSPQDYSS HSPPAPSQSE GVHWYSEILY RIGTWVLQED TIHPLGMAAK SS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Intercellular signal essential for a variety of patterning events during development and metamorphosis. Involved in limb formation, patterning of the central nervous system and ventral somite differentiation. Induces ectopic cement gland formation in embryos. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO.

Subcellular Location

[Sonic hedgehog protein C-product]: Secreted, extracellular space.; [Sonic hedgehog protein N-product]: Cell membrane; Lipid-anchor.

Protein Families

Hedgehog family

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