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Recombinant Cryptococcus neoformans var. neoformans serotype D Serine/threonine-protein kinase TEL1 (TEL1), partial

Recombinant Cryptococcus neoformans var. neoformans serotype D Serine/threonine-protein kinase TEL1 (TEL1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

TEL1

Uniprot NO.

P0CP60

Alternative Names

TEL1; CNF02070Serine/threonine-protein kinase TEL1; EC 2.7.11.1; ATM homolog; DNA-damage checkpoint kinase TEL1; Telomere length regulation protein 1

Species

Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)

Source

Yeast

Expression Region

1-2967

Target Protein Sequence

MDSVSGLHAA LSLCASDSAK DRARAHALLP PIFANAQNLR VFQAAAATHG GAPWLALFHC LFRAVALEKR AVLRGSSNAQ AAARLAHAIR IVRLVAEQAV HLIARKPLIA LVAHMRHQLV LPPRIFAPAL LDYSKALSTL LAYPPHVESL DRHTWLALMS MCFAAILGDD LVSDDQMDDA DMLGVAAELE RLDAENVPPH RPPVTLNTSS LVQIIPALLC STVSPIVPPT MKSGDTLTAG QKVGLGIVLK IRRFFTMYPH VTIYHLHLLT ALNTVLSDME LNCRDLFLLG SVKIFPHLVT LWAAPERDRD RRIPEQIAIA IHRILPHLAH SAELQGAQDV TENVERLMEM LAKESTMSRG IEPLDLGTFP STATPSRQST PSKRRKLENP LASLVSAVGM GRPESRLIAL QTLVFVIDRH WSKLAKDIQS DIRRTLVSLL TDDSETLQSW AYIALSTIIL SSYTAGANEN NNDENNNDGQ SQDDWKQVWS FALRKCHLPG PSRSASHAAA VLLQFDKVDS PSTIRGIQTM LTTIAVQGPP TAHDSVCALY SIALEAARSD IQLYSLNLEE QVLSWLEKTF AREKFERDKM DQRLDQATPG DILRLFSAVS RIQYHVPLAE PVTKEFLPDS AVVSYALERA KTQPIRDFLL YHTCPTPPPP PPPLDDSHTT PLLAASENHS TFLGGRPRRL SELLLSILNA TTAQWETKPV ISSGERPRRC VDLVALGLAF QGLLQLDGYI PHAACINAAI RLLHLLKPSL TSSDLSIPSL DLVWRGLRCL ADVPLAKEEE EEEEEDWPIL VKPDVQSGIR QDLLPPTMYD TPPQEEEAES SDPPKRFTQY PPTFPSTLLP TPTPITPSSL STFQSQSNSA SLVHAIWRLP DVSAALQGLF SVCLQVITRS SSSTSSGQPT QLSHHEDDDG EDDDDDFAVA SGETTSAPLP EKAAELRAST SLLRSAVAFR LQGVMLVSAG AGGGAQSKAY KDTQLVNSFL QADGLRAVEI GWAICEAMQK GWLRLGIDAV DLVVASLGNM LNSYGYARDE RLLQLCLEFL KCSAPVWMGN DHSNDDDLKD EAMRLVCYIA TKITAGSITS WRVRLAMLRF IEAFLHYDSA SKLWADCMVQ EEAEEEEDDV SMEDENHLFH YIAQSLSDPD MRVRARAATT AASALYRPSI HPSEHPIIYD QVSNSQAGDP TFAEHYLSYV LWKLNCCIAS AKQRQTVIFD LYEAAIGGTE YSDHLQAGLN AVARRLGLPS ITALYLPYAP TTTISHDTSR SSAITFVLNT THRLFGLSNR SAFFTACLEH AGAYMLYCGK IGLFTSACDA AGVLPEDLAL QLSVAAAAMA MALPLSNDKA TNVSMNKCKA EALALLSSFP GISGPDAAEE FLHSYANGVA AHLWELMDLE SSVDEIVAWF DKTEKESAAG IAFAQMMAHD NAKTGRVKAI NPAASFQSIH NVCRFLEKNY SSISLHAFTF AAILRLTSLI NNAFLVSEQR RYLRALAMLL SVHQGTLQRP LIWEAFLTET ITLLLQPDIC RTVLSMVMWA FDWLESLSST PSKLVNIFCQ LGEIRIELGG SGTPGSQPNQ MGDALEDWIV KMSPKWFKSQ ISQEAFERAV ALWPDSLRSR LSVHASPLSL RDLDDLSQND AVHNAGQLCK HFLHLADADH GQDVVSVFVD STFWSLKDKI SSVWDKEGIN AFQDLLYLCN GEVRAPSLNF YGQDTFSKAL NATTGEHKKT EAMNALYHAM CKTMVQLLHD RRPQIRSAAY RCLQRMKPIL TGKDLKELPA DVSDVVPILV PIPIGSVRQS QAMKLDGVIN NATWNKKAEH FATWSLELSR LLCKTASQHD KFFLSFEPLL STPLLPLHHF LGHFVHAALV CSRSMSSERS KAISEHFETV LQNPFASIEA VRSIVNIVLQ LRRYEHPFTS GMLGYNAWLS VNFVDLSKAA VKCGLYVSAL LFLELANDQG ESLDLAEPRV RQIMYDIYSN VEDPDGFYGI HNKDIRDSLR RRLEHEGLSW QALGWAGAVY NVDGNDSRSA IPVLHHLHDI GLSRLASVVA TETRTSGSVP LDDPFFADLS WRTGDWNLPI GRESSATSSG LLYSALSAVH RSKSYESASK IVDKAVRAEM TRLGGLQKEM LTSIQSTVTN LLCLRELNRW LDPQLQQGMQ EVIDKGTLRD LQDINDKFEF ASAERIIATR LSVFDSVKQR ESQDMIGDAL TPKMELVTKA ESTCHIKLSR LALKSNNLQA AINSLTALQK LQTYVGVIDE AQDVFCEVLW KQGEHTLAIQ LLEDLLLREK EKKSKGQRIP ALEGRLAHWA SEARLKAANE IFGMFSNVTK SIKRSTADVS EHAEIFYQFA CFADKQYVSQ SSSADVKQLK EYSKLRASQA LRLSARQSRA RESDQKDSAV REAERDEEKL KKFEMQQKQY LNAALQFYAE AVSMSDNFND CITRLVTLWL ENDENEESNV TFSRAAHKVP SYKFIFLGPQ LAARLHRPES PTIFNSTLNG LMFRMSQDHP YHTLYHVIPL LWEHKQPQST NSSMLGRKSA ADDIMRRLAS SASNRLAVGA AKSMKRFVAI AMEWTSFFEK DKRLEYKLPS DSPLRKAPRD IPVATSTPSI DVTCQYKDIA TFDHFSEWYT RAGGLSRPKV MTCFDSNGQK YTQLFKKDDG FRQDAVMEQI FVLVNDLLNR NRQTRSRKLR YRTYGVLALP EATGVIEFVV GTKPLIKYLP PAHEKYHPKD ITSHDFLKAM QEVQSVKNND EKIIQVWTKL KKRFRPVMRH LFTEKYRDPM AWFSMRLTYA RSLAVTSIVG WVLEIGDRHC SNILMDECTG ELVHIDFGIA FGAGRILPIP ELVPFRLTDD LVDALGVTGV NGTFRQCSQL VLQTLIDSSD VILTILEVFK QDPLHTWMVD DKMKKAQDGN HKMYPERGQE KADRIMRETR ENLSKELSVQ YRVNQLIQEA RDVNNLATIF RGWHSWL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.

Subcellular Location

Nucleus. Chromosome, telomere.

Protein Families

PI3/PI4-kinase family, ATM subfamily

Database Links

KEGG: cne:CNF02070

STRING: 214684.XP_571535.1

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