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Recombinant Coturnix coturnix japonica Insulin-like growth factor I (IGF1)

Recombinant Coturnix coturnix japonica Insulin-like growth factor I (IGF1)

Code
MSDS	MSDS
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

IGF1

Uniprot NO.

P51462

Species

Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)

Source

Yeast

Expression Region

20-89

Target Protein Sequence

G PETLCGAELV DALQFVCGDR GFYFSKPTGY GSSSRRLHHK GIVDECCFQS CDLRRLEMYC APIKPPKSA

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.

Subcellular Location

Secreted.

Protein Families

Insulin family

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