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Recombinant Chicken Transforming growth factor beta-3 (TGFB3)

Recombinant Chicken Transforming growth factor beta-3 (TGFB3)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

TGFB3

Uniprot NO.

P16047

Alternative Names

TGFB3; Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide; LAP); Transforming growth factor beta-3; TGF-beta-3)]

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

24-300

Target Protein Sequence

LSSCTTL DLEHIKKKRV EAIRGQILSK LRLTSPPESV GPAHVPYQIL ALYNSTRELL EEMEEEKEES CSQENTESEY YAKEIHKFDM IQGLPEHNEL GICPKGVTSN VFRFNVSSAE KNSTNLFRAE FRVLRVPNPS SKRSEQRIEL FQILRPDEHI AKQRYLSGRN VQTRGSPEWL SFDVTDTVRE WLLHRESNLG LEISIHCPCH TFQPNGDILE NLHEVLEIKF KGIDSEDDYG RGDLGRLKKQ KDLHNPHLIL MMLPPHRLES PTLGGQRKKR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.; Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3. Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3.; Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.

Gene References into Functions

The single nucleotide polymorphism and analyzed haplotypes identified in this study might be used as potential genetic markers in meat-type chicken breeding. PMID:23776260
MBNL1 negatively regulates cell invasion in the endocardial cushions by restricting the magnitude and timing of endocardial-derived TGFbeta3 production. PMID:22866814
Data show that bone morphogenetic proteins/TGFbetas/Wnts are necessary to regulate pattern formation and the specification of neural progenitor populations in the dorsal neural tube. PMID:15385163
TGFB3 inhibits chondrogenesis of cultured chicken leg bud mesenchymal cells via downregulation of connexin 43 and integrin beta4. PMID:17620312
TGF-beta1, TGF-beta2, TGF-beta3 have different roles in the embryonic nervous system of mouse and chicken PMID:18498095
gene expression and production of TGF-beta are high and are upregulated in healing tendon PMID:19084187
immunohistochemical localization of TGF-beta1, -2, and -3 in chick corneas during fibrotic wound repair PMID:19626665