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Recombinant Chicken Transcription factor SOX-9 (SOX9)

Recombinant Chicken Transcription factor SOX-9 (SOX9)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

SOX9

Uniprot NO.

P48434

Alternative Names

SOX9; Transcription factor SOX-9

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-494

Target Protein Sequence

MNLLDPFMKM TEEQDKGLSG APSPTMSDDS AGSPCPSGSG SDTENTRPPQ ENTFPKGDPD LKKESDEDKF PVCIREAVSQ VLKGYDWTLV PMPVRVNGSS KNKPHVKRPM NAFMVWAQAA RRKLADQYPH LHNAELSKTL GKLWRLLNES EKRPFVEEAE RLRVQHKKDH PDYKYQPRRR KTVKNGQSEQ EEGSEQTHIS PNAIFKALQA DSPQSSSSIS EVHSPGEHSG QSQGPPTPPT TPKTDAQQPG KQDLKREGPL AEGGRQPPHI DFRDVDIGEL SSDVISNIET FDVNEFDQYL PPNGHPGVPA THGQVTTYSG TYGISSSASS PAGAGHAWMA KQQPQPPQPP AQPPAQHTLP STEREQGPAQ QRPHIKTEQL SPSHNSEQQQ HPEQQQQQQQ QLGYGSFNLQ HYGFSYPPIT RSEYDYTEHQ NSGSYYSHAA GQSGSLYSTF TYMNPTQRPM YTPIADTSGV PTIPQTHSPQ QHWEQPVYTQ LTRP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination.

Gene References into Functions

Avian digits may represent an evolutionary specialization of digit development consequence of a posterior polarization of signals responsible for limb outgrowth. In contrast, the pentadactyl autopod of mouse and turtle embryos may result from the uniform expansion (like opening a fan) of the signals that coordinate proliferation and differentiation of the skeletal progenitors. PMID:28386540
Mechanical stimulation enhances nuclear signals of the transcription factors Sox9 and CREB in a PKA and PP2A-dependent manner PMID:24333667
The results suggest that ETS1 and SOX9 may act as pan-neural crest regulators of the migratory cranial neural crest PMID:24389048
data suggest a model in which extracellular signals initiate phosphorylation of Sox9 and its cooperation with Snail2 to induce NCC delamination PMID:23382206
Sox9 mediates the direct conversion of tenocytes to chondrocytes through an intermediate state in which both differentiation programs are active. Sox9 is expressed in cartilage but is undetectable in limb tendons that express Scleraxis and Tenomodulin. PMID:22510437
NFIA is a transcription factor that plays a crucial role in the onset of gliogenesis; we found that its induction is regulated by the transcription factor Sox9 and that this relationship mediates the initiation of gliogenesis PMID:22500632
model whereby Sox and Nfi proteins bind to conserved Matn1 proximal elements and functionally interact with each other to finely tune gene expression in specific zones of the cartilage growth plate PMID:21173167
Results suggest that SOX9 is necessary and sufficient to specify pyloric sphincter epithelial properties. PMID:15240557
Data suggest that Sox9 and Nkx2.5 are regulated independently by bone morphogenetic protein signaling, and act coordinately to specify the pyloric sphincter. PMID:15733673
PD098059 attenuated the depletion of cartilage matrix as well as decreased the expression and phosphorylation of Sox9 in cultures treated with H(2)O(2) or cyclosporine. PMID:15777799
Results demonstrate that RhoA-mediated modulation of actin polymerization regulates the ability of Sox9 to both activate chondrocyte-specific markers and maintain its own expression in chondrocytes via a positive feedback loop. PMID:19470758