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Recombinant Chicken Transcription factor SOX-2 (SOX2)

Recombinant Chicken Transcription factor SOX-2 (SOX2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

SOX2

Uniprot NO.

P48430

Alternative Names

SOX2; Transcription factor SOX-2; cSox2; delta EF2a

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-315

Target Protein Sequence

MYNMMETELK PPAPQQTSGG GTGNSNSAAN NQKNSPDRVK RPMNAFMVWS RGQRRKMAQE NPKMHNSEIS KRLGAEWKLL SEAEKRPFID EAKRLRALHM KEHPDYKYRP RRKTKTLMKK DKYTLPGGLL APGTNTMTTG VGVGATLGAG VNQRMDSYAH MNGWTNGGYG MMQEQLGYPQ HPGLNAHNAA QMQPMHRYDV SALQYNSMTS SQTYMNGSPT YSMSYSQQGT PGMALGSMGS VVKTESSSSP PVVTSSSHSR APCQAGDLRD MISMYLPGAE VPEPAAPSRL HMSQHYQSAP VPGTAINGTL PLSHM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.

Gene References into Functions

Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage. PMID:29352015
Data obtained in this study deciphers a novel role of hindbrain boundaries as repetitive pools of neural stem/progenitor cells, which provide proliferating progenitors and differentiating neurons in a Sox2-dependent regulation. PMID:27392568
Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system. PMID:24501124
Data indicate that cultured embryonic stem cells (cESCs) expressed pluripotency transcription factors, POUV, Sox-2, Nanog and Lin28 exhibited typical characteristics of pluripotency, even after six generations of rapid doubling. PMID:23314866
The results of this study suggested that high levels of Sox2 inhibit progression of neurogenesis in the developing inner ear PMID:23447599
Sensory competence is established early in otic development through the activation of Atoh1 by Sox2, however, hair cell differentiation is prevented until later stages by the parallel activation of negative regulators of Atoh1 function. PMID:22292066
A 110-bp minimal essential sequence of SOX2 regulatory enhancer element N-4 is identified, containing 9 regulatory elements involved in activation in cephalic ectoderm, in CNS and in mesencephalon. PMID:20507355
inhibits neural crest formation as a transcriptional activator and regulates proliferation and differentiation in developing peripheral nervous system PMID:14699579
involvement of Group B1 Sox functions in N-cadherin regulation via enhancers having activity in the early CNS and/or sensory placodes but with unique spatiotemporal specificities PMID:16150435
Wnt and FGF signals converge to activate Sox2 expression through the enhancer N-1c, revealing the direct involvement of the Wnt signal in the initiation of neural plate development. PMID:16354715
The present study shows that SOX2 protein is expressed in a spatially and temporally restricted manner throughout development of the chick inner ear. PMID:17534940
interactions between three coiled-coil domain proteins (ERNI, Geminin, and BERT), the heterochromatin proteins HP1alpha and HP1gamma acting as repressors, and the chromatin-remodeling enzyme Brm acting as activator control the N2 enhancer. PMID:18184035
Sox2 can initiate a reprogramming of retinal pigment epithelium cells to differentiate toward retinal neurons and may engage bFGF during the process. PMID:19489100

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Subcellular Location

Nucleus.

Tissue Specificity

First expressed in the embryonic neural plate shortly before closure and expression continues in the neural tube. From stage 16 onwards, expressed throughout the CNS including the brain, with expression predominant in the undifferentiated cells of the neu

Database Links

UNIGENE: Gga.601

KEGG: gga:396105

STRING: 9031.ENSGALP00000014363

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